Formoterol Impurity 59 CAS 306966-56-3
| CAS No. | 306966-56-3 |
| Molecular Formula | C16H16BrNO3 |
| Molecular Weight | 350.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 350.21 g/mol gives Formoterol Impurity 59 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Formoterol Impurity 59 (CAS 306966-56-3, C16H16BrNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Formoterol Impurity 59 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 350.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Formoterol Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16BrNO3 |
| Molecular Weight | 350.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Formoterol Standards
- Formoterol Impurity 28 (CAS 201677-59-0)
- Formoterol impurity 142 (CAS CATO-C4X-1525142)
- Formoterol Impurity 23 (CAS 43229-01-2)
- Formoterol Impurity 69 (CAS 100865-09-6)
- Formoterol-d6(Mixture of Diastereomers) (CAS 1020719-45-2)
- Formoterol impurity 126 (CAS CATO-C4X-1525126)
- Formoterol impurity 127 (CAS 188690-82-6)
- Formoterol Impurity 54 (CAS 193761-53-4)
Recommended Standards
- Crisaborole Impurity 61 (CAS CATO-C4X-202161)
- CAS 1361398-65-3 (CAS 1361398-65-3)
- Tert-butyl (5-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate (CAS 1105675-61-3)
- N-(4-Bromophenyl)-5-(4-fluorophenyl)-1,3,4-thiadiazol-2-amine (CAS 827580-60-9)
- Regorafenib Impurity 9 (CAS CATO-C4X-10479)
- Iguratimod Impurity 123 (CAS CATO-C4X-1826123)
- Gatifloxacin Impurity C79 (CAS 182868-72-0)
- n-(2-(1h-Pyrazol-1-yl)ethyl)-4-isopropylaniline (CAS 1272946-41-4)
- Methyl 4-(1-phenylethyl)-1H-pyrrole-3-carboxylate (CAS 1313712-50-3)
- 5'-Fluoro-2'-methyl-[1,1'-biphenyl]-3-carbaldehyde (CAS 1178198-86-1)
- 2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(5-(ethylthio)-1,3,4-thiadiazol-2-yl)acetamide (CAS 869067-91-4)
- Loratadine glucose adduct (CAS CATO-C4X-142640)
- 6-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (CAS 450-14-6)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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