4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid CAS 164164-26-5

Purity 97%+In StockPharmaceutical Standards
CAS No.164164-26-5
Molecular FormulaC13H8F2O2
Molecular Weight234.20 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid CAS 164164-26-5 chemical structure

Description

The occurrence of 4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 164164-26-5) is a high-purity analytical reference standard with the molecular formula C13H8F2O2 and a molecular weight of 234.20 g/mol.

4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid (C13H8F2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4,4'-Difluoro-[1,1'-biphenyl]-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC13H8F2O2
Molecular Weight234.20 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2003
Halogen ContentF-containing

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