Dorzolamide EP Impurity D CAS 164455-27-0
| CAS No. | 164455-27-0 |
| Molecular Formula | C8H12N2O4S3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Dorzolamide EP Impurity D (CAS 164455-27-0, C8H12N2O4S3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dorzolamide EP Impurity D (C8H12N2O4S3HCl) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Dorzolamide EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N2O4S3 HCl |
| Molecular Weight | 332.83 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 3 |
Related Dorzolamide Standards
- Dorzolamide Impurity 8 (CAS 120279-26-7)
- Dorzolamide EP Impurity A HCl (CAS 120279-36-9)
- Dorzolamide EP Impurity B HCl (CAS 120279-37-0)
- Dorzolamide EP Impurity A (CAS 120279-95-0)
- Dorzolamide (CAS 120279-96-1)
- Rac-Dorzolamide (CAS 120280-13-9)
- Dorzolamide EP Impurity A HCl (CAS 122028-36-8)
- Dorzolamide-d5 (CAS 1227097-70-2)
Recommended Standards
- Roxatidine Impurity 2 (CAS 97900-87-3)
- Cinitapride Impurity 18 (CAS CATO-C4X-290818)
- Imiquimod Impurity N3 (CAS 935521-01-0)
- 5-Bromo-N-(quinolin-8-yl)thiophene-2-sulfonamide (CAS 620103-87-9)
- N-[4-(5-methyl-1,3-benzothiazol-2-yl)phenyl]-5,6-dihydro-4H-1,3-thiazin-2-amine (CAS 380431-15-2)
- 9H-carbazole-3,6-dicarboxylic acid (CAS 3215-41-6)
- Diisopropyl ether (CAS 108-20-3)
- N-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-hydroxy-2-phenylacetamide (CAS 130256-21-2)
- 4-((((1,5-Dimethyl-1H-pyrazol-4-yl)methyl)amino)methyl)benzene-1,3-diol hydrochloride (CAS 1855943-55-3)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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