Linezolid impurity 106 CAS 1644566-15-3
| CAS No. | 1644566-15-3 |
| Molecular Formula | C17H14F2N2O3 |
| Molecular Weight | 332.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Linezolid impurity 106 (CAS 1644566-15-3, C17H14F2N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Linezolid impurity 106 (C17H14F2N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H14F2N2O3 |
| Molecular Weight | 332.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Linezolid Standards
- Linezolid Impurity 45 (CAS 168828-81-7)
- Linezolid Impurity 82 (CAS CATO-C4X-107382)
- Linezolid R-Isomer (CAS 872992-20-6)
- Linezolid (CAS 165800-03-3)
- Linezolid Impurity 4 (CAS 496031-56-2)
- Linezolid Ipurity 84 (CAS CATO-C4X-107384)
- Linezolid impurity 103 (CAS CATO-C4X-1073103)
- Linezolid-d3 (CAS 1127120-38-0)
Recommended Standards
- Enzalutamide Impurity 53 (CAS CATO-C4X-101653)
- Levothyroxine Impurity 49 (CAS 106822-80-4)
- 4569AC 887267-77-8 C13H11F3N2O3S Ethyl 2-amino-4-(4-(trifluoromethoxy)phenyl)thiazole-5-carboxylate (CAS 887267-77-8)
- Fezolinetant Impurity 25 (CAS CATO-C4X-327025)
- Ticagrelor Impurity N2 (CAS 1354951-34-0)
- Ketorolac Impurity 44 (CAS CATO-C4X-166944)
- Letrozole Impurity 14 (CAS 2451658-74-3)
- (S)-1-(4-Bromophenyl)-N-methylethanamine hydrochloride (CAS 1810074-73-7)
- Tert-butyl ethyl(2-((2-hydroxyethyl)amino)cyclohexyl)carbamate (CAS 1353955-96-0)
- 4-Cyclopropoxy-3-fluorobenzamide (CAS 1243354-44-0)
- 2,2'-((2,4-Dihydroxybenzyl)azanediyl)diacetic acid (CAS 337493-89-7)
- 5-Bromo-2-nitrobenzofuran (CAS 30335-67-2)
- 1-(3-Bromopropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one (CAS 864267-63-0)
- Peptide 439 (CAS CATO-CPTD788439)
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