Dutasteride Impurity 5 CAS 164656-22-8
| CAS No. | 164656-22-8 |
| Molecular Formula | C27H32F6N2O2 |
| Molecular Weight | 530.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dutasteride Impurity 5 (CAS 164656-22-8) is a certified pharmaceutical impurity reference standard with the molecular formula C27H32F6N2O2 and a molecular weight of 530.55 g/mol.
Structurally, Dutasteride Impurity 5 (C27H32F6N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 530.55 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Dutasteride Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H32F6N2O2 |
| Molecular Weight | 530.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dutasteride Standards
- Dutasteride-d3Discontinued, see D735004 (CAS 1131341-46-2)
- Dutasteride Impurity N88 (CAS 164656-21-7)
- Dutasteride EP Impurity E(Relative stereochemistry) (CAS 1796930-46-5)
- 5beta-Dutasteride (CAS 957229-52-6)
- Dutasteride Impurity 14 (CAS CATO-C4X-110314)
- Dutasteride EP Impurity E (Dutasteride 17-alpha-epimer) (CAS 2102935-76-0)
- Dutasteride (CAS 164656-23-9)
- Dutasteride-13C6 (CAS 1217685-27-2)
Recommended Standards
- BMS-599626 (CAS 714971-09-2)
- (4-(1-(2-Methoxy-3-(trifluoromethyl)-[1,1-biphenyl]-4-carbonyl)azetidin-3-yl)piperazin-1-yl)(thiazol-2-yl)methanone (CAS 1252771-06-4)
- GSK-1838705A (CAS 1186659-59-5)
- O,O-(Butane-1,4-diyl) bis(4-hydroxybutyl) Diterephthalate (CAS 29278-67-9)
- Fruquintinib Impurity 14 (CAS CATO-C4X-303714)
- Piroxicam EP Impurity A (CAS 504-29-0)
- Valsartan EP Impurity A (CAS 137862-87-4)
- 3-(Boc-amino)-3-(4-piperidyl)propanoic Acid (CAS 372144-03-1)
- 2-(4-Bromophenoxy)-3-chloro-5-(trifluoromethyl)pyridine (CAS 1036492-02-0)
- 1,5-Dichlorohexamethyltrisiloxane (CAS 3582-71-6)
- 4-(4-(1-Methyl-1H-pyrazol-4-yl)phenyl)piperidine hydrochloride (CAS 2007909-10-4)
- (3-Chloro-2-fluorophenyl)methanesulfonamide (CAS 1564853-25-3)
- Ethyl 2-nitro-5-(trifluoromethyl)benzoate (CAS 1214325-74-2)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
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