tert-Butyl 4-((2-chloro-6-methoxyquinazolin-4-yl)amino)piperidine-1-carboxylate CAS 1648895-40-2
| CAS No. | 1648895-40-2 |
| Molecular Formula | C19H25ClN4O3 |
| Molecular Weight | 392.88 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
tert-Butyl 4-((2-chloro-6-methoxyquinazolin-4-yl)amino)piperidine-1-carboxylate (CAS 1648895-40-2), molecular formula C19H25ClN4O3 and molecular weight 392.88 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, tert-Butyl 4-((2-chloro-6-methoxyquinazolin-4-yl)amino)piperidine-1-carboxylate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 392.88 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H25ClN4O3 |
| Molecular Weight | 392.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Recommended Standards
- N-(2-Benzoyl-4-chlorophenyl)-2-{[(1R)-1-phenylethyl]amino}acetamide (CAS 1616506-47-8)
- tert-Butyl 4-((2-chloro-7-methoxyquinazolin-4-yl)amino)piperidine-1-carboxylate (CAS 1648895-41-3)
- N-(2-Benzoyl-4-chlorophenyl)-2-{[(1S)-1-phenylethyl]amino}acetamide (CAS 1616506-46-7)
- 2-((4-Chlorophenyl)sulfonyl)-N-(4-phenylthiazol-2-yl)acetamide (CAS 338965-88-1)
- Tert-butyl 4-(5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)piperazine-1-carboxylate (CAS 1062118-80-2)
- 4-(Piperidin-4-ylmethyl)aniline (CAS 37581-35-4)
- 6-bromocinnoline (CAS 318276-72-1)
- 3-(Benzenesulfonyl)-4,6-dimethylpyridin-2-yl 2-chloro-6-fluorobenzoate (CAS 400083-86-5)
- 3-Bromo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (CAS 66017-97-8)
- 4-((Allyloxy)methyl)-3-fluorobenzenethiol (CAS 1379212-76-6)
- (2S,4R)-4-Hydroxy-N-(2-methylnaphthalen-1-yl)pyrrolidine-2-carboxamide (CAS 2170816-89-2)
- Lisinopril Impurity 28 (CAS 1207346-27-7)
- 2-(4-Amino-6-chloropyridin-2-yl)acetic acid (CAS 1393574-23-6)
- D-Trp25-Tirzepatide (CAS CATO-CPTD788909)
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