Ritonavir EP Impurity B（HCl） CAS 165315-97-9
| CAS No. | 165315-97-9 |
| Molecular Formula | C28H36N4O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ritonavir EP Impurity B（HCl） (C28H36N4O4SHCl) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ritonavir EP Impurity B（HCl） (CAS 165315-97-9, C28H36N4O4SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ritonavir EP Impurity B（HCl） meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H36N4O4S HCl |
| Molecular Weight | 561.14 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ritonavir Standards
- Ritonavir EP Impurity C (CAS 1010808-43-1)
- Ritonavir EP Impurity K (CAS 1010809-39-8)
- Ritonavir EP Impurity H (CAS 1010809-43-4)
- Ritonavir Impurity 45 (CAS 1010809-50-3)
- Ritonavir Impurity 46 (CAS 1010809-54-7)
- Ritonavir EP Impurity F (CAS 1010809-61-6)
- Ritonavir Dehydro (CAS 1156504-13-0)
- Ritonavir-13C3 (CAS 1217673-23-8)
Recommended Standards
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- N-(4-Chlorophenyl)-4-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzamide (CAS 338396-96-6)
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- 2-(Indolin-3-yl)acetic acid (CAS 13083-41-5)
- Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 81858-94-8)
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