Ritonavir Impurity 46 CAS 1010809-54-7
| CAS No. | 1010809-54-7 |
| Molecular Formula | C32H42N4O8S |
| Molecular Weight | 642.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ritonavir Impurity 46 (CAS 1010809-54-7) is a certified pharmaceutical impurity reference standard with the molecular formula C32H42N4O8S and a molecular weight of 642.76 g/mol.
Ritonavir Impurity 46 (C32H42N4O8S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ritonavir Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H42N4O8S |
| Molecular Weight | 642.76 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ritonavir Standards
- Ritonavir Impurity 45 (CAS 1010809-50-3)
- Ritonavir EP Impurity L (CAS 256328-82-2)
- Ritonavir Impurity A RRT 5.78 (CAS 959351-57-6)
- Ritonavir EP Impurity I (CAS 165315-26-4)
- Ritonavir EP Impurity H (CAS 1010809-43-4)
- Ritonavir EP Impurity D (CAS 144142-33-6)
- Ritonavir Dehydro (CAS 1156504-13-0)
- Ritonavir Impurity 61 (CAS CATO-C4X-175161)
Recommended Standards
- Ezetimibe Impurity 77 (CAS CATO-C4X-109877)
- H-Arg-Arg-Arg-Arg-OH (CAS 26791-46-8)
- 3,3'-((2,5-Dimethylpiperazine-1,4-diyl)bis(methylene))bis(5,5-diphenylimidazolidine-2,4-dione) (CAS 5545-94-8)
- 4,5-O-Isopropylidene-3,6-bis-O-(phenylmethyl)-1-O-(triphenylmethyl) DL-myo-Inositol (CAS 114218-25-6)
- Roxadustat Impurity N5 (CAS 1509958-20-6)
- Nelfinavir Oxazole Impurity (Impurity A) (CAS 188936-07-4)
- Mesalazine EP Impurity E (CAS 65-49-6)
- 4-[(2-oxopiperazin-1-yl)methyl]benzonitrile hydrochloride (CAS 239072-80-1)
- (+)-alfa-Longipinene (CAS 5989-08-2)
- 2-Bromo-3-cyclopropoxy-N-methylbenzamide (CAS 1243313-64-5)
- 95408-38-1 Iron(2+) 1-(di-tert-butylphosphanyl)cyclopenta-2,4-dien-1-ide 1-(diphenylphosphanyl)cyclopenta-2,4-dien-1-ide (1/1/1) DTXSID00746613 (CAS 95408-38-1)
- 6,7-Dichloro-2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine (CAS 19918-41-3)
- Pcb No. 70 (CAS 32598-11-1)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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