Bromhexine EP Impurity E CAS 1660957-93-6
| CAS No. | 1660957-93-6 |
| Molecular Formula | C15H21Br2N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromhexine EP Impurity E.
Bromhexine EP Impurity E (CAS 1660957-93-6) is a certified pharmaceutical impurity reference standard with the molecular formula C15H21Br2N2Cl and a molecular weight of 424.60 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution, Bromhexine EP Impurity E is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 424.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bromhexine EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H21Br2N2 Cl |
| Molecular Weight | 424.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromhexine Standards
- Bromhexine Impurity 35 (CAS 100-60-7)
- Bromhexine impurity 59 (CAS 100669-81-6)
- Bromhexine Impurity 51 (CAS 100669-82-7)
- Bromhexine EP Impurity D(2HCl) (CAS 10076-98-9)
- Bromhexine Impurity 22 (CAS 114059-99-3)
- Bromhexine Impurity 17 (CAS 114390-40-8)
- Bromhexine Impurity N3 (CAS 114390-41-9)
- Bromhexine impurity 60 (CAS 1261676-18-9)
Recommended Standards
- Avatrombopag Impurity 95 (CAS CATO-C4X-223495)
- Landiolol Impurity 69 (CAS CATO-C4X-262169)
- Ceftolozane impurity 3 (CAS 1956303-47-1)
- N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-Trimethylammonium Iodide (CAS 868594-57-4)
- 2-((3-Cyano-4,6-bis(4-methoxyphenyl)pyridin-2-yl)thio)-N-(naphthalen-1-yl)acetamide (CAS 332114-63-3)
- 1-(4-(2-Amino-4-chlorophenyl)piperazin-1-yl)-3-methylbutan-1-one (CAS 879590-35-9)
- 1-(4-Bromopyridin-3-yl)cyclopropane-1-carboxylic acid (CAS 1785054-30-9)
- 5-Chloro-3-phenyl-1H-indole-2-carboxylic acid (CAS 21139-31-1)
- 3-Chloro-5-methoxy-1H-pyrrolo[3,2-b]pyridine (CAS 1190311-31-9)
- (Leu31,Pro3?)-Neuropeptide Y (porcine) trifluoroacetate salt (CAS 125580-28-1)
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