Bromhexine impurity 59 CAS 100669-81-6
| CAS No. | 100669-81-6 |
| Molecular Formula | C7H6Br3N |
| Molecular Weight | 343.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 343.84 g/mol gives Bromhexine impurity 59 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Bromhexine impurity 59 (CAS 100669-81-6) is a certified pharmaceutical impurity reference standard with the molecular formula C7H6Br3N and a molecular weight of 343.84 g/mol.
Bromhexine impurity 59 (C7H6Br3N) contains a nitrile group, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6Br3N |
| Molecular Weight | 343.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromhexine Standards
- Bromhexine Impurity 7 (CAS 1631131-52-6)
- Bromhexine Related Compound 2 (CAS 32193-43-4)
- Bromhexine Impurity N1 (CAS 14860-48-1)
- Bromhexine Impurity N3 (CAS 114390-41-9)
- Bromhexine Impurity 50 (CAS 18683-92-6)
- Bromhexine (CAS 3572-43-8)
- Bromhexine Impurity 38 (CAS CATO-C4X-106038)
- Bromhexine Impurity 34 (CAS 606-00-8)
Recommended Standards
- 5-Bromo-2,3-bis(bromomethyl)pyridine (CAS 905273-34-9)
- 1024769-57-0 Aza(3-(4-chloro-3-methylphenyl)-7,7-dimethyl(6,7,8-trihydrocinnolin-5-ylidene))ethoxymethane MFCD00245682 (CAS 1024769-57-0)
- 3-Methyl-2,4,6-tribromoaniline (CAS 71642-16-5)
- 9-(4-(tert-Butyl)benzyl)-2-chloro-N,N-dimethyl-9H-purin-6-amine (CAS 115204-58-5)
- Maxacalcitol Impurity 9 (CAS 103909-73-5)
- Tadalafil Impurity 25 (CAS CATO-C4X-108725)
- Clopidogrel Impurity 130 (CAS CATO-C4X-1029130)
- 4-(tert-Butyldimethylsilyloxy)phenylboronic Acid (contains varying amounts of Anhydride) (CAS 159191-56-7)
- 5-Oxo-5-(4-trifluoromethylphenyl)valeric acid (CAS 88699-88-1)
- (S)-3-amino-3-(3,5-dibromophenyl)propanoic acid hydrochloride (CAS 1270112-78-1)
- 2-(aminophenylmethylene)indane-1,3-dione (CAS 85301-69-5)
- Aripiprazole Impurity 75 (CAS 1782324-31-5)
- 4-(3-Aminophenyl)-5-hydroxyisoquinolin-1(2H)-one (CAS 656234-41-2)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
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