Agomelatine Impurity 45 CAS 166527-00-0
| CAS No. | 166527-00-0 |
| Molecular Formula | C14H15NO3 |
| Molecular Weight | 245.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Agomelatine Impurity 45 (CAS 166527-00-0, C14H15NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Agomelatine Impurity 45 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 245.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15NO3 |
| Molecular Weight | 245.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Nitrogen Atoms | 1 |
Related Agomelatine Standards
- Agomelatine Impurity 19 (CAS 1352139-51-5)
- Agomelatine Impurity 20 (CAS 178677-39-9)
- Agomelatine-D3 (CAS 107389-38-0)
- Agomelatine-d4 (CAS 1079389-44-8)
- Agomelatine (CAS 138112-76-2)
- Agomelatine Impurity 47 (CAS CATO-C4X-110847)
- Agomelatine Impurity 35 (CAS 178677-49-1)
- Agomelatine Impurity 42 (CAS CATO-C4X-110842)
Recommended Standards
- 898753-50-9 Ethyl 5-(4-cyanophenyl)-5-oxopentanoate DTXSID40645636 (CAS 898753-50-9)
- Ac-Glu(OtBu)-OH (CAS 84192-88-1)
- Boc-Hyp-Ome (CAS 74844-91-0)
- Boc-cis-Hyp-OMe (CAS 102195-79-9)
- Febuxostat Impurity 74 (CAS 1312815-36-3)
- Tegoprazan impurity 48 (CAS CATO-C4X-229748)
- Methotrexate EP Impurity A HCl (CAS 73978-41-3)
- 5-(2-Methoxyphenyl)-5-oxovaleric acid (CAS 105253-92-7)
- [S(R)]-N-[(S)-[2-(Dicyclohexylphosphino)phenyl]-2-naphthalenylmethyl]-N,2-dimethyl-2-propanesulfinamide (CAS 2565792-44-9)
- Methyl 3-methyl-[1,1'-biphenyl]-2-carboxylate (CAS 941320-77-0)
- 5-Fluoro-1H-indol-1-amine (CAS 666828-90-6)
- Potassium 4-chloro-2-(thiophene-2-carboxamido)benzoate (CAS 1011405-11-0)
- 2-(2-Chloroethyl)-6-(ethylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 860648-66-4)
- 3X Flag Peptide trifluoroacetate salt (CAS 402750-12-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com