Agomelatine Impurity 47 CAS CATO-C4X-110847
| CAS No. | CATO-C4X-110847 |
| Molecular Formula | C14H13NO3 |
| Molecular Weight | 243.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Agomelatine Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Agomelatine Impurity 47 (CAS CATO-C4X-110847) is a certified pharmaceutical impurity reference standard with the molecular formula C14H13NO3 and a molecular weight of 243.26 g/mol.
The molecular framework of Agomelatine Impurity 47 (C14H13NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H13NO3 |
| Molecular Weight | 243.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Agomelatine Standards
- Agomelatine-d4 (CAS 1079389-44-8)
- Agomelatine (CAS 138112-76-2)
- Agomelatine Impurity 42 (CAS CATO-C4X-110842)
- Agomelatine Impurity 50 (CAS CATO-C4X-110850)
- Agomelatine Impurity 45 (CAS 166527-00-0)
- Agomelatine Impurity 19 (CAS 1352139-51-5)
- Agomelatine Impurity 20 (CAS 178677-39-9)
- Agomelatine-D3 (CAS 107389-38-0)
Recommended Standards
- (1S,4S)-5-(tert-Butoxycarbonyl)-2-oxa-5-azabicyclo[2.2.1]heptane-4-carboxylic acid (CAS 2920198-60-1)
- Sorafenib EP Impurity A (CAS 284462-37-9)
- 932334-10-6 4-{[(3-Aminopyridin-2-yl)amino]methyl}benzoic acid MFCD15732379 (CAS 932334-10-6)
- Sorafenib Impurity 54 (CAS 1153328-25-6)
- Famotidine Impurity 42 (CAS CATO-C4X-139242)
- Carbidopa EP Impurity A (CAS 555-30-6)
- Ponatinib Impurity 19 (CAS CATO-C4X-226919)
- Thioctic Acid Impurity N8 (CAS 41443-60-1)
- 2-Amino-3,5-dibromophenol (CAS 116632-17-8)
- 2-Isobutyramido-2-methylpropanoic acid (CAS 118728-63-5)
- 2-(3,4-Dimethylbenzoyl)benzoic acid (CAS 2159-42-4)
- (1-Methyl-1H-imidazol-2-yl)(1-phenylcyclopropyl)methanamine hydrochloride (CAS 2138054-90-5)
- 639824-67-2 2-Nitrobenzenesulfenyl chloride-13C6 DTXSID30440334 (CAS 639824-67-2)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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