Digoxin EP Impurity C CAS 1672-46-4
| CAS No. | 1672-46-4 |
| Molecular Formula | C23H34O5 |
| Molecular Weight | 390.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Digoxin EP Impurity C is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Digoxin EP Impurity C (CAS 1672-46-4) is a certified pharmaceutical impurity reference standard with the molecular formula C23H34O5 and a molecular weight of 390.51 g/mol.
Digoxin EP Impurity C (C23H34O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H34O5 |
| Molecular Weight | 390.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Digoxin Standards
Recommended Standards
- Lovastatin EP Impurity A (CAS 73573-88-3)
- Latanoprost EP Impurity H (CAS 41639-83-2)
- Simvastatin EP Impurity I (CAS 79902-42-4)
- Treprostinil (CAS 81846-19-7)
- Chlormadinone Acetate EP Impurity K (CAS 425-51-4)
- Levodopa Impurity 20 (CAS 33043-37-7)
- Cinitapride Impurity 15 (CAS CATO-C4X-290815)
- (±)-Neoisomenthol (CAS 491-02-1)
- 4-Methylumbelliferyl 3-deoxy-D-glycero-α-D-galacto-2-nonulosonic acid sodium salt (CAS 123269-95-4)
- 4-(2,5-Dichlorophenoxy)-3-methylisoxazolo[5,4-d]pyrimidine (CAS 672925-32-5)
- 5-methyl-3-(pyrrolidin-3-yl)-1H-1,2,4-triazole hydrochloride (CAS 1909337-02-5)
- 4-[(1H-1,2,4-Triazol-1-yl)methyl]piperidine (CAS 1211590-58-7)
- Cinitapride Impurity 22 (CAS CATO-C4X-290822)
- Des-Ser39-Tirzepatide (CAS CATO-CPTD788936)
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