Niclosamide Impurity 2 CAS 16739-20-1
| CAS No. | 16739-20-1 |
| Molecular Formula | C13H8Cl2N2O4 |
| Molecular Weight | 327.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Niclosamide Impurity 2.
As a process- or degradation-related impurity, Niclosamide Impurity 2 (CAS 16739-20-1, C13H8Cl2N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Niclosamide Impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 327.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Niclosamide Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H8Cl2N2O4 |
| Molecular Weight | 327.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Niclosamide Standards
- Niclosamide (CAS 50-65-7)
- 13C6-Niclosamide hydrate (CAS 1325559-12-3)
- Niclosamide-13C6 (CAS 1325808-64-7)
- Niclosamide Impurity 4 (CAS 16739-21-2)
- Niclosamide Impurity 3 (CAS 4638-49-7)
- Niclosamide Impurity 5 (CAS 32853-24-0)
- Niclosamide Monohydrate (CAS 73360-56-2)
- Niclosamide Piperazine Salt (CAS 34892-17-6)
Recommended Standards
- Dotinurad Impurity 26 (CAS CATO-C4X-249426)
- Pyridoxine impurity 84 (CAS CATO-C4X-187784)
- 3-[5-(2-bromo-5-methoxyphenyl)-1,3,4-oxadiazol-2-yl]propanoic acid (CAS 1179591-56-0)
- n-(Furan-2-ylmethyl)-4-iodobenzamide (CAS 329209-85-0)
- Tizanidine Impurity 51 (CAS CATO-C4X-144551)
- Elobixibat Impurity 23 (CAS 439088-54-7)
- Roxadustat Impurity 4 (CAS CATO-C4X-22134)
- 8-Chloronaphthalene-2-sulfonyl chloride (CAS 85915-71-5)
- Methyl 1-oxoisochromane-3-carboxylate (CAS 17225-04-6)
- 6-Methoxy-2,2-dimethylchroman-4-ol (CAS 65383-71-3)
- 1-(2-Methoxy-2-(o-tolyl)ethyl)-3-(2-(trifluoromethyl)phenyl)urea (CAS 1797338-82-9)
- 2-Chloroanisole (CAS 766-51-8)
- 1,4-Dimethoxy-2-naphthoic acid (CAS 78265-13-1)
- Retatrutide (CAS 2381089-83-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com