Niclosamide Impurity 3 CAS 4638-49-7
| CAS No. | 4638-49-7 |
| Molecular Formula | C13H9ClN2O4 |
| Molecular Weight | 292.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Niclosamide Impurity 3.
As a process- or degradation-related impurity, Niclosamide Impurity 3 (CAS 4638-49-7, C13H9ClN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Niclosamide Impurity 3 (C13H9ClN2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Niclosamide Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9ClN2O4 |
| Molecular Weight | 292.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Niclosamide Standards
- Niclosamide Impurity 5 (CAS 32853-24-0)
- Niclosamide Impurity 2 (CAS 16739-20-1)
- Niclosamide (CAS 50-65-7)
- 13C6-Niclosamide hydrate (CAS 1325559-12-3)
- Niclosamide-13C6 (CAS 1325808-64-7)
- Niclosamide Impurity 4 (CAS 16739-21-2)
- Niclosamide Monohydrate (CAS 73360-56-2)
- Niclosamide Piperazine Salt (CAS 34892-17-6)
Recommended Standards
- Olanzapine Impurity 21 (CAS 60091-87-4)
- 398486-54-9 diethyl (Z)-(2-(4-chlorophenyl)-1-fluorovinyl)phosphonate (CAS 398486-54-9)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)piperidin-4-one (CAS 1057282-45-7)
- N-(2-Chloro-4-nitrophenyl)-3-(furan-2-yl)acrylamide (CAS 853349-20-9)
- Nikethamide Impurity 14 (CAS 77727-88-9)
- Gemcitabine Impurity 28 (CAS 134790-40-2)
- Venetoclax Impurity 3 (CAS CATO-C4X-24953)
- 5-Ethynylpicolinamide (CAS 1314640-56-6)
- 2-Bromo-N-(furan-3-ylmethyl)-N-(2-(thiophen-2-yl)ethyl)benzenesulfonamide (CAS 1797246-37-7)
- 3-(4-Methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)propan-1-one (CAS 898776-07-3)
- 1-Benzyl-N-(2-nitrobenzyl)piperidin-4-amine (CAS 98754-28-0)
- 3-Cyclobutylpyrazolo[1,5-a]pyrimidin-6-amine (CAS 1707369-79-6)
- 5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)picolinic acid (CAS 1519937-82-6)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com