Cabozantinib Impurity 43 CAS 1677-29-8
| CAS No. | 1677-29-8 |
| Molecular Formula | C15H12F2N2O2 |
| Molecular Weight | 290.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Cabozantinib Impurity 43 (CAS 1677-29-8), molecular formula C15H12F2N2O2 and molecular weight 290.26 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Cabozantinib Impurity 43 (C15H12F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Cabozantinib Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12F2N2O2 |
| Molecular Weight | 290.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 22 (CAS CATO-C4X-201822)
- Cabozantinib Impurity 49 (CAS CATO-C4X-201849)
- Cabozantinib Impurity (CAS 190728-27-9)
- Cabozantinib Impurity 32 (CAS 202917-04-2)
- Cabozantinib Impurity 11 (CAS 748707-58-6)
- Cabozantinib Impurity 21 (CAS 190728-25-7)
- Cabozantinib Impurity 8 (CAS 213699-53-7)
- Cabozantinib Impurity 42 (CAS CATO-C4X-201842)
Recommended Standards
- N,N'-Bis(2-fluorophenyl)propanediamide (CAS 152167-97-0)
- 3-(Methylsulfonyl)-4-(4-(trifluoromethyl)phenyl)-1H-pyrazole (CAS 1707747-00-9)
- 2,2,2-Trifluoro-N-(4-(4-fluorophenyl)piperidin-3-yl)acetamide (CAS 1432680-12-0)
- 1-((4-(Trifluoromethyl)phenyl)sulfonyl)-1H-pyrrol-3-amine (CAS 1934285-35-4)
- 1-Butyl-1H-imidazole-2-carbaldehyde (CAS 169378-52-3)
- 1-(tert-Butoxy)hexane (CAS 69775-79-7)
- 2-{[4-(trifluoromethyl)phenyl]amino}-4H-3,1-benzoxazin-4-one (CAS 278609-56-6)
- 1-(3-Amino-4-methylphenyl)pyrrolidine-2,5-dione (CAS 946753-47-5)
- 1-({2,3-dicyanoimidazo[1,2-a]pyrimidin-6-yl}sulfanyl)-n,n-dimethylformamide (CAS 1235441-73-2)
- Simvastatin Acyl-β-D-glucuronide (CAS 463962-56-3)
- Tert-butyl 1-methyl-1,6-diazaspiro[3.5]Nonane-6-carboxylate (CAS 1268522-34-4)
- 2-Phenylpropane-1,3-diamine (CAS 55165-09-8)
- 2-(4-(Hydroxymethyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione (CAS 1072960-82-7)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
Why CATO?
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