Cabozantinib Impurity 42 CAS CATO-C4X-201842
| CAS No. | CATO-C4X-201842 |
| Molecular Formula | C17H16N2O4 |
| Molecular Weight | 312.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Cabozantinib Impurity 42 (CAS CATO-C4X-201842) is a certified pharmaceutical impurity reference standard with the molecular formula C17H16N2O4 and a molecular weight of 312.32 g/mol.
Cabozantinib Impurity 42 (C17H16N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16N2O4 |
| Molecular Weight | 312.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 5 (CAS 849217-60-3)
- Cabozantinib Impurity 3 (CAS 1431468-36-8)
- Cabozantinib Impurity 8 (CAS 213699-53-7)
- Cabozantinib Impurity 48 (CAS CATO-C4X-201848)
- Cabozantinib Impurity 2 (CAS 190728-24-6)
- Cabozantinib Impurity (CAS 190728-27-9)
- Cabozantinib Impurity 32 (CAS 202917-04-2)
- Cabozantinib Impurity 11 (CAS 748707-58-6)
Recommended Standards
- Esmolol Impurity 36 (CAS CATO-C4X-189136)
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- Iopromide Impurity 27 (CAS CATO-C4X-183227)
- Nivalenol (CAS 23282-20-4)
- Vildagliptin Impurity 6 (CAS 1789703-36-1)
- Crisaborole Impurity 138 (CAS CATO-C4X-2021138)
- Baloxavir Impurity 46 (CAS CATO-C4X-210846)
- 2-Chloro-N,N-dipropylbenzamide (CAS 349397-59-7)
- Ethyl 2-(4-hydroxybenzenesulfonyl)acetate (CAS 866150-07-4)
- 1-(2-Fluoro-3-nitrophenyl)ethanone (CAS 873697-78-0)
- 2-Bromo-6h-thieno[2,3-b]pyrrole-5-carboxylic acid (CAS 332098-83-6)
- 5-Cyano-2-phenyl-N-(o-tolyl)isoxazolidine-3-carboxamide (CAS 62513-12-6)
- (1,8-Dioxa-4-azaspiro[5.5]undecan-4-yl)(6-(trifluoromethyl)-1H-indol-2-yl)methanone (CAS 2223749-52-6)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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