Cabozantinib Impurity 22 CAS CATO-C4X-201822
| CAS No. | CATO-C4X-201822 |
| Molecular Formula | C18H18N2O2 |
| Molecular Weight | 294.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cabozantinib Impurity 22 (CAS CATO-C4X-201822, C18H18N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cabozantinib Impurity 22 (C18H18N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18N2O2 |
| Molecular Weight | 294.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 49 (CAS CATO-C4X-201849)
- Cabozantinib Impurity (CAS 190728-27-9)
- Cabozantinib Impurity 32 (CAS 202917-04-2)
- Cabozantinib Impurity 11 (CAS 748707-58-6)
- Cabozantinib Impurity 21 (CAS 190728-25-7)
- Cabozantinib Impurity 43 (CAS 1677-29-8)
- Cabozantinib Impurity 8 (CAS 213699-53-7)
- Cabozantinib Impurity 42 (CAS CATO-C4X-201842)
Recommended Standards
- Tolvaptan Impurity 60 (CAS CATO-C4X-195560)
- Troxipide (CAS 30751-05-4)
- Lacosamide Impurity 60 (CAS CATO-C4X-183060)
- Troxipide Impurity 24 (CAS 55306-70-2)
- Sunitinib Impurity 45 (CAS 443-69-6)
- Methoxamine Impurity 8 (CAS CATO-C4X-20228)
- Avatrombopag Impurity 9 (CAS 2401867-89-6)
- Tegoprazan impurity 50 (CAS 3007659-89-1)
- n-(1-(3-Chlorophenyl)propyl)prop-2-en-1-amine (CAS 1019537-65-5)
- 4-(Fluoromethyl)-5-iodo-6-(trifluoromethoxy)picolinic acid (CAS 1806746-04-2)
- Methyl 2-(3-fluoro-4-methylphenyl)-2-hydroxyacetate (CAS 1340349-14-5)
- 2-(2-((((Benzyloxy)carbonyl)amino)methyl)pyrrolidin-1-yl)acetic acid (CAS 1353966-84-3)
- 2-tert-Butylindolizine-3-carbaldehyde (CAS 83164-31-2)
- Semaglutide Impurity 1(OtBu-Ste-D-γGlu(OtBu)-AEEA-AEEA-OH) (CAS CATO-C4X-22261)
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