Rifapentine impurity 22 CAS 75922-14-4
| CAS No. | 75922-14-4 |
| Molecular Formula | C37H45NO13 |
| Molecular Weight | 711.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Rifapentine impurity 22 (C37H45NO13) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Rifapentine impurity 22 (CAS 75922-14-4, C37H45NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H45NO13 |
| Molecular Weight | 711.75 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 1 |
Related Rifapentine Standards
- Rifapentine Impurity 13 (CAS CATO-C4X-195913)
- Rifapentine Impurity 14 (CAS CATO-C4X-195914)
- Rifapentine impurity 17 (CAS CATO-C4X-195917)
- Rifapentine impurity 24 (CAS CATO-C4X-195924)
- Rifapentine impurity 25 (CAS CATO-C4X-195925)
- Rifapentine Impurity 7 (CAS 27557-15-9)
- Rifapentine impurity 20 (CAS CATO-C4X-195920)
- Rifapentine Impurity N1 (3-Formyl-Desacetyl Rifapentine) (CAS 16783-97-4)
Recommended Standards
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- Maribavir Impurity 28 (CAS CATO-C4X-300728)
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- 2-(Piperidin-4-yl)benzo[d]oxazole (CAS 51784-03-3)
- 3-aminothieno[3,2-b]pyridine-6-carbonitrile (CAS 116538-96-6)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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