Loratadine Impurity 5 CAS 167891-69-2
| CAS No. | 167891-69-2 |
| Molecular Formula | C22H25ClN2O2 |
| Molecular Weight | 384.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 384.90 g/mol gives Loratadine Impurity 5 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Loratadine Impurity 5 (CAS 167891-69-2) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25ClN2O2 and a molecular weight of 384.90 g/mol.
The molecular framework of Loratadine Impurity 5 (C22H25ClN2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loratadine Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H25ClN2O2 |
| Molecular Weight | 384.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine-d4 (CAS 381727-27-1)
- Loratadine (CAS 79794-75-5)
- Loratadine EP Impurity E (CAS 170727-59-0)
- Loratadine EP Impurity 41 (CAS 169253-13-8)
- Loratadine Impurity 79 (CAS CATO-C4X-142679)
- Loratadine impurity 84 (CAS CATO-C4X-142684)
- Loratadine-d5 (CAS 1020719-57-6)
- Loratadine-d5 (ethyl-d5) (CAS 1398065-63-8)
Recommended Standards
- N-{[4-Allyl-5-(allylsulfanyl)-4H-1,2,4-triazol-3-yl]methyl}-4-chlorobenzenesulfonamide (CAS 338422-31-4)
- Pyrimorph (CAS 868390-90-3)
- Ethyl 2-({4-[(4-chlorophenyl)sulfanyl]-5-methoxypyrimidin-2-yl}sulfanyl)propanoate (CAS 338423-63-5)
- 4-((3-Chlorophenyl)thio)-6-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (CAS 478247-61-9)
- Urapidil Impurity 90 (CAS CATO-C4X-192490)
- Clopidogrel Impurity 5 (CAS CATO-C4X-10295)
- Aripiprazole Impurity 78 (CAS CATO-C4X-100878)
- 7-Fluoro-6-methyl-3,4-dihydronaphthalen-1(2H)-one (CAS 182182-24-7)
- 2,3-dihydro-1-benzofuran-2-carbaldehyde (CAS 36054-77-0)
- Methyl 3-Nitro-4-indazolecarboxylate (CAS 1260385-51-0)
- 1-(4-Fluorophenoxy)-3-(4-(4-nitrophenyl)piperazin-1-yl)propan-2-ol (CAS 1254122-84-3)
- 2-amino-4-chloro-1,3-thiazole-5-carbonitrile (CAS 136195-53-4)
- 1-Bromo-3,5-difluoro-2-(trifluoromethoxy)benzene (CAS 1242259-73-9)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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