Loratadine CAS 79794-75-5
| CAS No. | 79794-75-5 |
| Molecular Formula | C22H23ClN2O2 |
| Molecular Weight | 382.88 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Loratadine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Loratadine (CAS 79794-75-5), molecular formula C22H23ClN2O2 and molecular weight 382.88 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Loratadine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 382.88 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C22H23ClN2O2 |
| Molecular Weight | 382.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine EP Impurity E (CAS 170727-59-0)
- Loratadine EP Impurity 41 (CAS 169253-13-8)
- Loratadine Impurity 80 (CAS CATO-C4X-142680)
- Loratadine Impurity 16 (CAS CATO-C4X-142616)
- Loratadine Impurity 17 (CAS 133330-56-0)
- Loratadine Impurity 28 (CAS CATO-C4X-142628)
- Loratadine Impurity 88 (CAS CATO-C4X-142688)
- Loratadine Impurity 5 (CAS 167891-69-2)
Recommended Standards
- 5-(3-Chlorophenyl)-3-(naphthalen-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (CAS 329779-78-4)
- 2,5-Di(thiophen-2-yl)thiazole (CAS 54987-01-8)
- Desloratadine Impurity 31 (CAS 109537-11-3)
- (1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate (CAS 148702-58-3)
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