Ezetimibe Impurity 71 CAS CATO-C4X-109871
| CAS No. | CATO-C4X-109871 |
| Molecular Formula | C31H27F2NO3 |
| Molecular Weight | 499.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ezetimibe Impurity 71 (C31H27F2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Ezetimibe Impurity 71 (CAS CATO-C4X-109871), a pharmacopoeial impurity reference standard (molecular formula C31H27F2NO3, MW 499.55 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C31H27F2NO3 |
| Molecular Weight | 499.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 79 (CAS 1683564-73-9)
- Ezetimibe Impurity 10 (CAS CATO-C4X-109810)
- Ezetimibe Impurity 14(Intermediate Impurity) (CAS 163222-32-0)
- Ezetimibe Impurity 9 (CAS 163380-15-2)
- Ezetimibe Impurity 91 (CAS 851860-29-2)
- Ezetimibe Impurity 133 (CAS CATO-C4X-1098133)
- Ezetimibe Impurity 12(Intermediate Isomer Impurity) (CAS CATO-C4X-109812)
- Ezetimibe Impurity 8 (CAS CATO-C4X-10988)
Recommended Standards
- 10R-0297 6,7-dimethoxy-3-(2-phenylethyl)-2-({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)-3,4-dihydroquinazolin-4-imine 691858-06-7 (CAS 691858-06-7)
- L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]- (CAS 1363155-71-8)
- N-(tert-Butoxycarbonyl)colchicine (CAS 186374-94-7)
- (S)-Methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-phenylpropanoate (CAS 63328-40-5)
- Dolutegravir Impurity 47 (CAS CATO-C4X-162047)
- Teneligliptin Impurity 14 (CAS CATO-C4X-176014)
- Bicalutamide EP Impurity A (CAS 90357-05-4)
- N-[2-(5-Amino-4H-1,2,4-triazol-3-yl)ethyl]benzamide (CAS 108921-95-5)
- ethyl 4-bromoquinoline-6-carboxylate (CAS 958332-97-3)
- 4-Bromo-1-methyl-1,2-dihydro-3H-pyrazol-3-one (CAS 1823437-48-4)
- [(Chloromethyl)sulfanyl]ethane (CAS 1708-73-2)
- ((2e,4e)-3-Methyl-5-(2,6,6-trimethylcyclohex-2-en-1-yl)penta-2,4-dien-1-yl)triphenylphosphonium bromide (CAS CATO-C1455351)
- 2-(4-Chloro-benzoylamino)-3-methyl-pentanoic acid (CAS 1396967-36-4)
- Osteoblast-Adhesive Peptide (CAS 193613-75-1)
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