Dipyridamole EP Impurity A CAS 16982-40-4
| CAS No. | 16982-40-4 |
| Molecular Formula | C25H40N8O2 |
| Molecular Weight | 484.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dipyridamole EP Impurity A (CAS 16982-40-4, C25H40N8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dipyridamole EP Impurity A (C25H40N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H40N8O2 |
| Molecular Weight | 484.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 8 |
Related Dipyridamole Standards
- Dipyridamole EP Impurity F (CAS 60286-30-8)
- Dipyridamole (CAS 58-32-2)
- Dipyridamole EP Impurity E (CAS 2365420-11-5)
- Dipyridamole EP Impurity D (CAS 1176886-12-6)
- Dipyridamole-d16 (CAS CATO-C4X-161810)
- Dipyridamole EP Impurity B (CAS 16908-47-7)
- Dipyridamole D20 (CAS 1189983-52-5)
- Dipyridamole Tartaric Acid Mono Ester (CAS 68006-07-5)
Recommended Standards
- N-[(1R,2S,5R)-2-[(S)-3-[[7-(tert-Butyl)pyrazolo[1,5-a][1,3,5]triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]-5-(tert-butylamino)cyclohexyl]acetamide (CAS 1286279-29-5)
- Ro-41-5253 (CAS 144092-31-9)
- (SP-4-3)-Chloro[2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl-κN3]-N-[2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl-κN3]phenyl]benzenaminato-κN]nickel (CAS 1215122-54-5)
- 5-Methyl-1-phenylpyrimidine-2,4(1H,3H)-dione (CAS 1484-93-1)
- Mesalazine Impurity 47 (CAS 13300-63-5)
- Micafungin Impurity 24 (CAS CATO-C4X-169524)
- Doxofylline Impurity 15 (CAS CATO-C4X-151315)
- 4'-Chloro-2,3-difluoro-1,1'-biphenyl (CAS 477860-10-9)
- H-D-Ala-Gly-Gly-OH (CAS 77286-90-9)
- 1-Oxo-1-phenylpropan-2-yl 2H-chromene-3-carboxylate (CAS 1111537-61-1)
- 5-Hydroxy-1,8-naphthyridin-2(1H)-one (CAS 37905-96-7)
- 4-(Difluoromethyl)-3,6-diiodopicolinoyl chloride (CAS 1805158-39-7)
- 2-(2-Methyl-6-(methylamino)pyridin-3-yl)piperidine-1-carbaldehyde (CAS 1352502-49-8)
- Human glucagon CRS (CAS 9007-92-5)
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