Posaconazole Impurity 74 CAS 170985-86-1
| CAS No. | 170985-86-1 |
| Molecular Formula | C44H48F2N8O4 |
| Molecular Weight | 790.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Posaconazole Impurity 74 (CAS 170985-86-1, C44H48F2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Posaconazole Impurity 74 (C44H48F2N8O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C44H48F2N8O4 |
| Molecular Weight | 790.90 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Posaconazole Standards
- Posaconazole Impurity 274 (CAS CATO-C4X-1208274)
- Posaconazole impurity 250 (CAS CATO-C4X-1208250)
- Posaconazole impurity 251 (CAS CATO-C4X-1208251)
- Posaconazole Impurity 80 (CAS 1488301-79-6)
- Posaconazole Benzoate (CAS CATO-C4X-1208194)
- Posaconazole Impurity 88 (CAS CATO-C4X-1208188)
- Posaconazole Impurity 170 (CAS CATO-C4X-1208170)
- Posaconazole Impurity 205 (CAS CATO-C4X-1208205)
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