Pitavastatin Impurity 6 CAS 172336-33-3
| CAS No. | 172336-33-3 |
| Molecular Formula | C27H28FNO4 |
| Molecular Weight | 449.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Pitavastatin Impurity 6 (CAS 172336-33-3, C27H28FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Pitavastatin Impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 449.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pitavastatin Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H28FNO4 |
| Molecular Weight | 449.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Pitavastatin Standards
- Pitavastatin Impurity N2 (CAS 167073-19-0)
- Pitavastatin Ethyl Ester (CAS 172336-32-2)
- Pitavastatin Impurity 110 (CAS CATO-C4X-1037110)
- Pitavastatin 3-Oxo Ethyl Ester (CAS 148901-69-3)
- Pitavastatin Impurity 109 (CAS CATO-C4X-1037109)
- Pitavastatin Impurity 135 (CAS CATO-C4X-1037135)
- Pitavastatin Impurity 51 (CAS 1187966-93-3)
- Pitavastatin Impurity 69 (CAS CATO-C4X-103769)
Recommended Standards
- Avanafil Impurity 148 (CAS CATO-C4X-1118148)
- Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-5-formyl-2,6-diisopropylnicotinate (CAS 618892-25-4)
- Avanafil Impurity 6 (CAS 330784-50-4)
- 2-Ethoxy-d5-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester (CAS 1795133-18-4)
- Relugoli Impurity 140 (CAS CATO-C4X-2429140)
- Picosulfate impurity 19 (CAS CATO-C4X-123719)
- Articaine EP Impurity A HCl (CAS 1712677-79-6(free base))
- 1-Methyl-3-pyrrolidinol (CAS 13220-33-2)
- Terizidone Impurity 4 (CAS CATO-C4X-30544)
- Pramipexole Impurity 94 (CAS CATO-C4X-110794)
- 3-(Perfluoroethoxy)aniline (CAS 717-84-0)
- 6-Methyl-3-((3-nitrobenzyl)thio)-1,2,4-triazin-5(4H)-one (CAS 872629-62-4)
- tert-Butyl 2-ethyl-4-oxopiperidine-1-carboxylate (CAS 324769-07-5)
- [14-31]-Semaglutide (CAS CATO-C4X-2226262)
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