Azithromycin EP Impurity I CAS 172617-84-4
| CAS No. | 172617-84-4 |
| Molecular Formula | C37H70N2O12 |
| Molecular Weight | 734.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Azithromycin EP Impurity I (CAS 172617-84-4), a pharmacopoeial impurity reference standard (molecular formula C37H70N2O12, MW 734.96 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Azithromycin EP Impurity I (C37H70N2O12) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Azithromycin EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H70N2O12 |
| Molecular Weight | 734.96 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Nitrogen Atoms | 2 |
Related Azithromycin Standards
- Azithromycin EP Impurity A (CAS 76801-85-9)
- Azithromycin EP Impurity C (CAS 620169-47-3)
- Azithromycin EP Impurity B (CAS 307974-61-4)
- Azithromycin impurity 53 (CAS 152727-04-3)
- Azithromycin CP Impurity Q (CAS 99290-97-8)
- Azithromycin CP Impurity R (CAS 161193-44-8)
- Azithromycin Impurity 23 (CAS CATO-C4X-100323)
- Azithromycin Impurity 50 (CAS CATO-C4X-100350)
Recommended Standards
- （See C4X-100319）Azithromycin EP Impurity A (See C4X-100319) (CAS CATO-C4X-10037)
- Dirithromycin EP impurity A (CAS 26116-56-3)
- β-hederin (CAS 35790-95-5)
- (17S)-20-Deoxysalinomycin (CAS 64129-77-7)
- Palbociclib Impurity 87 HCl (CAS 2174002-29-8(free base))
- Doripenem Impurity 4 (CAS CATO-C4X-16214)
- Melphalan EP Impurity C DiHCl (CAS 896715-19-8)
- 2-(tert-Butyl)-4-cyclopropoxy-1-(trifluoromethyl)benzene (CAS 1243369-88-1)
- 1-(Chloromethyl)-2-fluoro-4-methylbenzene (CAS 147541-99-9)
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- cis-1-Cbz-3-amino-4-(hydroxymethyl)pyrrolidine (CAS 252770-09-5)
- Ganirelix 1-4 peptide (CAS 208599-57-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com