Lamivudine EP impurity A CAS 173602-25-0
| CAS No. | 173602-25-0 |
| Molecular Formula | C8H9N3O4S |
| Molecular Weight | 243.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lamivudine EP impurity A.
As a process- or degradation-related impurity, Lamivudine EP impurity A (CAS 173602-25-0, C8H9N3O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lamivudine EP impurity A (C8H9N3O4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9N3O4S |
| Molecular Weight | 243.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lamivudine Standards
- Lamivudine EP Impurity A(2R,5S)Monomer (CAS 173829-09-9)
- Lamivudine Impurity 42 (CAS CATO-C4X-119442)
- Lamivudine Impurity 1 (CAS 1235712-40-9)
- Lamivudine Impurity 18 (CAS CATO-C4X-119418)
- Lamivudine EP Impurity G (CAS 160552-55-6)
- Lamivudine EP Impurity H (CAS 160552-54-5)
- Lamivudine Impurity 43 (CAS CATO-C4X-119443)
- Lamivudine Impurity 44 (CAS CATO-C4X-119444)
Recommended Standards
- Diethyl (amino(phenyl)methyl)phosphonate (CAS 16814-08-7)
- 1-(4-Fluorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 936758-09-7)
- 1-(3-Fluorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1538794-47-6)
- 2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyrimidin-5-ol (CAS 866050-49-9)
- Tucatinib Impurity 51 (CAS CATO-C4X-260551)
- Bevantolol Impurity 33 (CAS CATO-C4X-241133)
- Bumetanide Impurity 123 (CAS CATO-C4X-1986123)
- (R)-1-(2-Chlorophenyl)propan-1-ol (CAS 151508-76-8)
- 1-(1-Isopropyl-1H-benzo[d]imidazol-2-yl)-N-methylmethanamine dihydrochloride (CAS 1245569-28-1)
- 2-[2-(2-Chloro-6,7-dimethoxyquinolin-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione (CAS 1105193-51-8)
- 2,2'-Disulfanediylbis(4-fluoroaniline) (CAS 63755-07-7)
- 2-(1H-imidazo[4,5-b]pyridin-2-yl)ethan-1-amine dihydrochloride (CAS 3324-08-1)
- 1-(4-Aminoindolin-1-yl)-2-methylpropan-1-one (CAS 1342001-12-0)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788679)
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