Efavirenz Impurity 16 CAS 173676-59-0
| CAS No. | 173676-59-0 |
| Molecular Formula | C8H5ClF3NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 278.05 g/mol gives Efavirenz Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Efavirenz Impurity 16 (CAS 173676-59-0, C8H5ClF3NOHClH2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H5ClF3NOHClH2O, Efavirenz Impurity 16 contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 278.05 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Efavirenz Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF3NO HCl H2O |
| Molecular Weight | 278.05 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- rac Efavirenz-d5(major) (CAS 1132642-95-5)
- Efavirenz Impurity 5 (CAS 1189491-03-9)
- Efavirenz Impurity (6-chloro-4-[2-(2-methylcyclopropyl)ethynyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) (CAS 1217623-65-8)
- rac Efavirenz-d4 (CAS 1246812-58-7)
- Efavirenz 2-Desoxo-2-methly (CAS 1258498-53-1)
- Efavirenz-13C6 (CAS 1261394-62-0)
- Efavirenz Impurity 15 (CAS 127641-25-2)
- Efavirenz (CAS 154598-52-4)
Recommended Standards
- Ibuprofen Impurity 49 (CAS 1161014-75-0)
- Palbociclib Impurity 10 (CAS CATO-C3D-1457)
- Oxomemazine impurity 1 (CAS CATO-C4X-29531)
- 2-(Bromomethyl)-4-chloro-1,3-difluorobenzene (CAS 261762-47-4)
- 6-Bromobenzo[e][1,2,3]oxathiazine 2,2-dioxide (CAS 115540-65-3)
- 2-(Cyclohexylamino)-4,6-dimethylnicotinonitrile (CAS 142591-25-1)
- 4-Methoxybenzofuran-6-ol (CAS 858792-95-7)
- 2-((2-Amino-1H-purin-6-yl)thio)-2-bromo-1-phenylethanone (CAS 61631-52-5)
- 2-(1-Oxoisoquinolin-2(1H)-yl)acetic acid (CAS 59139-93-4)
- Cholecystokinin Octapeptide (1-3) (desulfated) H-Asp-Tyr-Met-OH (CAS 121880-94-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com