Efavirenz CAS 154598-52-4
| CAS No. | 154598-52-4 |
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Efavirenz (CAS 154598-52-4) is a high-purity analytical reference standard with the molecular formula C14H9ClF3NO2 and a molecular weight of 315.67 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Efavirenz is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 315.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 2 (CAS 154801-74-8)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
- Efavirenz Impurity 25 (CAS CATO-C4X-162725)
- Efavirenz Impurity 28 (CAS CATO-C4X-162728)
- Efavirenz Racemate (CAS 177530-93-7)
- Efavirenz 2-Desoxo-2-methly (CAS 1258498-53-1)
- Efavirenz USP Related Compound B (CAS 440124-96-9)
Recommended Standards
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- Indacaterol Impurity 20 (CAS 2250243-41-3)
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