2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid methyl ester CAS 175137-27-6
| CAS No. | 175137-27-6 |
| Molecular Formula | C7H10ClF3N2O2 |
| Molecular Weight | 246.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid methyl ester.
2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid methyl ester (CAS 175137-27-6) is a high-purity analytical reference standard with the molecular formula C7H10ClF3N2O2 and a molecular weight of 246.61 g/mol.
Based on its molecular formula C7H10ClF3N2O2, 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid methyl ester contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 246.61 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid methyl ester meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H10ClF3N2O2 |
| Molecular Weight | 246.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-6-fluoro-2-(methylthio)-5-(trifluoromethyl)pyrimidine (CAS 115441-09-3)
- Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)amino)acetate (CAS 859307-58-7)
- 5-Chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole (CAS 1076197-51-7)
- 4-Chloro-6-methyl-7-(trifluoromethyl)quinazoline (CAS 1160994-15-9)
- 3-Chloro-7-(trifluoromethyl)quinolin-4-amine (CAS 1203579-71-8)
- 4-(4-Chloro-3-fluoro-2-hydroxyphenyl)-4-oxobutanoic acid (CAS 1208265-79-5)
- 2-Chloro-4-(trifluoromethyl)quinolin-7-amine (CAS 1416439-79-6)
- 4-Chloro-2-methyl-6-(trifluoromethyl)quinazoline (CAS 1422284-63-6)
Recommended Standards
- Ethyl 6-amino-2-chloro-5-nitropyrimidine-4-carboxylate (CAS 15949-13-0)
- 5-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-1,2,4-oxadiazole-3-carbonyl chloride (CAS 2736511-27-4)
- 3-(3-Chloropropanoyl)-1-(3,3,3-trifluoropropyl)urea (CAS 1340452-19-8)
- 8-Chloro-2-(difluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 2514942-10-8)
- 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyrimidine (CAS 1111638-06-2)
- 1,2-Dichloro-3-Nitro-4-(Trifluoromethyl)Benzene (CAS 133391-72-7)
- ([3-(3,4-DImethylphenyl)-1-adamantyl]methyl)amine hydrochloride (CAS 136611-72-8)
- 2-(1H-Imidazol-1-yl)acetonitrile (CAS 98873-55-3)
- (2Z)-3-[(3-Acetylphenyl)amino]-2-(4-methylbenzenesulfonyl)prop-2-enenitrile (CAS 1025668-88-5)
- methyl (1s,3s,4r)-2-azabicyclo[2.2.2]oct-5-ene-3-carboxylate (CAS 748723-37-7)
- 3-(4-Fluorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS 2089325-31-3)
- L-Isoleucine-2-d1 (CAS 127290-60-2)
- 4-Amino-1-(3-chloro-2-pyridyl)piperidine hydrochloride, 97% (CAS 77145-35-8)
- Peptide Impurity 26 (CAS 1350456-66-4)
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