4-Hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylic acid CAS 175203-86-8
| CAS No. | 175203-86-8 |
| Molecular Formula | C11H6F3NO4 |
| Molecular Weight | 273.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylic acid.
CATO supplies 4-Hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylic acid (CAS 175203-86-8), a certified reference material (molecular formula C11H6F3NO4, MW 273.16 g/mol) for analytical method development and quality control.
The molecular framework of 4-Hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylic acid (C11H6F3NO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H6F3NO4 |
| Molecular Weight | 273.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 4-Hydroxy-7-(trifluoromethoxy)quinoline-3-carboxylic acid (CAS 53985-74-3)
- 6-Hydroxy-2-((5-nitrofuran-2-yl)methylene)benzofuran-3(2H)-one (CAS 17817-38-8)
- 3,3'-((6-Hydroxy-1,3,5-triazine-2,4-diyl)bis(oxy))dipropionic acid (CAS 2904-40-7)
- 3-Hydroxy-2,4,6-trinitrobenzoic acid (CAS 33927-45-6)
- 3-Hydroxy-4-nitro-benzoic Acid Phenylmethyl Ester (CAS 123015-42-9)
- Benzyl 2-Hydroxy-5-nitrobenzoate (CAS 155388-71-9)
- 3-Hydroxy-N-(4-methylpyridin-3-yl)-4-nitrobenzamide (CAS 1797793-89-5)
- 4-Hydroxy-7-isopropoxy-6-nitroquinoline-3-carbonitrile (CAS 919482-01-2)
Recommended Standards
- 1-(3,4-Dichlorophenyl)cyclohexane-1-carboxylic acid (CAS 162733-00-8)
- 2-(Difluoromethyl)-3-methoxy-6-(trifluoromethoxy)pyridine-5-methanol (CAS 1804478-89-4)
- 2-Chloro-1-[3-(2-chloroacetyl)-2,4,6-trimethylphenyl]ethan-1-one (CAS 156641-43-9)
- 2-(Difluoromethyl)-6-methoxy-3-(trifluoromethoxy)pyridine-4-methanol (CAS 1804479-09-1)
- 3-(4-((Tert-butyldimethylsilyl)oxy)-2-chlorophenyl)azetidin-3-ol (CAS 2166106-04-1)
- Ethyl 7-(2,6-dimethylpyridin-4-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 40034-74-0)
- Tenofovir Disoproxil Desmethyl Fumarate (CAS 1798422-29-3)
- 2-(5-(2-Aminoethyl)-1,2,4-oxadiazol-3-yl)acetamide hemioxalate (CAS 1820614-77-4)
- (Z)-4-Acetoxy-3-(4-(methylsulfonyl) phenyl)-2-phenylbut-2-enoic acid (CAS 179174-79-9)
- 3-[(Benzylamino)sulfonyl]-4-bromobenzoic acid (CAS 312758-94-4)
- (2E)-3-(2,5-Dihydroxyphenyl)acrylic acid (CAS 636-01-1)
- 4-Amino-2-cyclopropylpyrimidine-5-carbonitrile (CAS 23662-47-7)
- Ethyl 2-Isopropyloxazole-4-carboxylate (CAS 1060814-30-3)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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