3-Chloro-5-(trifluoromethyl)pyridine-2-carbothioamide CAS 175277-46-0
| CAS No. | 175277-46-0 |
| Molecular Formula | C7H4ClF3N2S |
| Molecular Weight | 240.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
3-Chloro-5-(trifluoromethyl)pyridine-2-carbothioamide (CAS 175277-46-0), molecular formula C7H4ClF3N2S and molecular weight 240.63 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-5-(trifluoromethyl)pyridine-2-carbothioamide (C7H4ClF3N2S) contains a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF3N2S |
| Molecular Weight | 240.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 5-Chloro-3',4'-difluoro-[1,1'-biphenyl]-3-ol (CAS 1261902-17-3)
- 3-Chloro-5-(3,5-difluorophenyl)phenol (CAS 1261919-72-5)
- 3-Chloro-5-(2,3-difluorophenyl)phenol (CAS 1261960-95-5)
- 5-Chloro-2',5'-difluoro-[1,1'-biphenyl]-3-ol (CAS 1261990-27-5)
- 3-Chloro-5-(2,4-difluorophenyl)phenol (CAS 1262002-54-9)
- 5-Chloro-2',6'-difluoro-[1,1'-biphenyl]-3-ol (CAS 1262002-75-4)
- 2-Chloro-2,2-difluoro-1-(naphthalen-1-yl)ethan-1-one (CAS 1352209-82-5)
- Methyl 5-chloro-3,6-dimethylisoxazolo[5,4-b]pyridine-4-carboxylate (CAS 1011398-40-5)
Recommended Standards
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- 4-(Trifluoromethylthio)benzoyl Chloride (CAS 330-14-3)
- 4-Chloro-3-(2-oxoimidazolidin-1-yl)benzoic acid (CAS 1042623-41-5)
- 3-[2-(2-Chloro-5-methylphenoxy)ethyl]piperidinehydrochloride (CAS 1219960-60-7)
- Phenyl chloromethanesulfonate (CAS 16764-29-7)
- 4-Methoxy-5-(tributylstannyl)pyrimidin-2-amine (CAS 597551-31-0)
- 2-(5-(4-(Benzyloxy)phenyl)-2H-tetrazol-2-yl)acetic acid (CAS 890091-60-8)
- Bufexamac impurity D CRS (CAS 3413-59-0)
- 2,2-Dimethylchromane-6-carbaldehyde (CAS 61370-75-0)
- 3,3-Dimethyl-N-(pentan-3-yl)cyclohexan-1-amine (CAS 1409791-29-2)
- 3-(Benzo[d]oxazol-2-yl)-2-methylaniline (CAS 313549-87-0)
- 3-Bromo-2-(difluoromethoxy)-5-isopropylbenzaldehyde (CAS 2404734-25-2)
- Semaglutide impurity 108 (CAS CATO-C4X-2226108)
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