Ketorolac Impurity 53 CAS 175459-90-2
| CAS No. | 175459-90-2 |
| Molecular Formula | C16H13NO5 |
| Molecular Weight | 299.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ketorolac Impurity 53 (CAS 175459-90-2, C16H13NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ketorolac Impurity 53 (C16H13NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 299.28 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H13NO5 |
| Molecular Weight | 299.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Nitrogen Atoms | 1 |
Related Ketorolac Standards
- Ketorolac impurity 75 (CAS CATO-C4X-166975)
- Ketorolac Isopropyl Ester (CAS 66635-74-3)
- Ketorolac Impurity 40 (CAS CATO-C4X-166940)
- Ketorolac Impurity 21 (CAS CATO-C4X-166921)
- Ketorolac impurity 66 (CAS CATO-C4X-166966)
- Ketorolac impurity 69 (CAS 66635-89-0)
- Ketorolac EP Impurity D (CAS 1391053-45-4)
- Ketorolac EP Impurity G (CAS 1391051-90-3)
Recommended Standards
- Isoniazid Impurity 12 (CAS 4241-73-0)
- Metaraminol Impurity 66 (CAS CATO-C4X-225266)
- Levosimendan Impurity 40 (CAS CATO-C4X-130840)
- Metaraminol Impurity 76 (CAS CATO-C4X-225276)
- Pitavastatin Impurity N1 (CAS 147511-70-4)
- N-Nitroso Lurasidone Impurity 65 (CAS CATO-C4X-102865)
- Mitiglinide impurity 23 (CAS CATO-C4X-116123)
- Methyl (2S,4S)-4-(4-bromo-2-chlorophenoxy)-2-pyrrolidinecarboxylate hydrochloride (CAS 1354487-92-5)
- N-Benzyl-7-methyl-7-azaspiro[3.5]nonan-2-amine (CAS 1352925-58-6)
- n-(Tert-butyl)-2-(pyrimidin-2-ylamino)acetamide (CAS 1036147-19-9)
- Phenyl(1H-pyrazol-4-yl)methanol (CAS 37599-31-8)
- Methyl 2-3-anhydro-4-6-O-benzylidene-α-D-allopyranose (CAS 3150-15-0)
- THiopropazate (CAS 84-06-0)
- Neuropeptide Y (3-36) (porcine) trifluoroacetate salt (CAS 143863-88-1)
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