Ketorolac impurity 66 CAS CATO-C4X-166966
| CAS No. | CATO-C4X-166966 |
| Molecular Formula | C15H14ClNO3 |
| Molecular Weight | 291.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ketorolac impurity 66 (CAS CATO-C4X-166966) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14ClNO3 and a molecular weight of 291.73 g/mol.
Ketorolac impurity 66 (C15H14ClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ketorolac impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14ClNO3 |
| Molecular Weight | 291.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ketorolac Standards
- Ketorolac Impurity 21 (CAS CATO-C4X-166921)
- Ketorolac impurity 69 (CAS 66635-89-0)
- Ketorolac Isopropyl Ester (CAS 66635-74-3)
- Ketorolac EP Impurity D (CAS 1391053-45-4)
- Ketorolac EP Impurity G (CAS 1391051-90-3)
- Ketorolac Impurity 53 (CAS 175459-90-2)
- Ketorolac impurity 75 (CAS CATO-C4X-166975)
- Ketorolac EP Impurity J (CAS 108061-03-6)
Recommended Standards
- Phenyl N-[(3-chloro-4-methoxyphenyl)methyl]carbamate (CAS 692733-08-7)
- Ozefloxacin Impurity 23 (CAS 2767548-40-1)
- N-(3-Chloro-4-methoxyphenyl)-4-methoxybenzamide (CAS 331989-75-4)
- N-Desmethylclobazam-d5 (CAS 129973-75-7)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
- Cefotaxime Impurity 64 (CAS CATO-C4X-120164)
- Minoxidil Impurity 13 (CAS 64344-76-9)
- l-Isopinocampheol (CAS 1196-00-5)
- 2-Chloro-4,5-dihydroxybenzaldehyde (CAS 37686-56-9)
- (R)-Ethyl 2,2-dimethylcyclopropanecarboxylate (CAS 91603-11-1)
- 2-(2,4-Dimethoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acid (CAS 356578-82-0)
- Zosuquidar (CAS 167354-41-8)
- 1-(3-Isopropyl-1-methyl-1h-pyrazol-4-yl)-N-methylmethanamine (CAS 1158052-79-9)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
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