Ketorolac impurity 69 CAS 66635-89-0
| CAS No. | 66635-89-0 |
| Molecular Formula | C15H12ClNO3 |
| Molecular Weight | 289.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ketorolac impurity 69 (CAS 66635-89-0, C15H12ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ketorolac impurity 69 (C15H12ClNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H12ClNO3 |
| Molecular Weight | 289.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ketorolac Standards
- Ketorolac impurity 66 (CAS CATO-C4X-166966)
- Ketorolac Impurity 21 (CAS CATO-C4X-166921)
- Ketorolac EP Impurity D (CAS 1391053-45-4)
- Ketorolac EP Impurity G (CAS 1391051-90-3)
- Ketorolac EP Impurity J (CAS 108061-03-6)
- Ketorolac Impurity 25 (CAS CATO-C4X-166925)
- Ketorolac Impurity 30 (CAS CATO-C4X-166930)
- Ketorolac Isopropyl Ester (CAS 66635-74-3)
Recommended Standards
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- Difamilast Impurity 7 (CAS 1574285-43-0)
- α-D-Thiomannose sodium salt (CAS 111057-34-2)
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