Fenbufen EP Impurity A CAS 17589-68-3
| CAS No. | 17589-68-3 |
| Molecular Formula | C9H7ClO3 |
| Molecular Weight | 198.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fenbufen EP Impurity A is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Fenbufen EP Impurity A (CAS 17589-68-3, C9H7ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fenbufen EP Impurity A (C9H7ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClO3 |
| Molecular Weight | 198.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Fenbufen Standards
- Fenbufen impurity 7 (CAS CATO-C4X-19397)
- Fenbufen 4-Chlorophenyl Butanoic Acid (CAS 3984-34-7)
- Fenbufen Impurity 9 (CAS 644-90-6)
- Fenbufen Impurity 2 (Fenbufen EP Impurity B) (CAS 34682-12-7)
- Fenbufen EP Impurity B (CAS CATO-C4X-19392)
- Fenbufen (CAS 36330-85-5)
- Fenbufen-d9 (CAS 1189940-96-2)
- Fenbufen Methyl Ester (CAS 54011-27-7)
Recommended Standards
- Clopidogrel Impurity 98 (CAS 76103-96-3)
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- 2-Deoxy-2-chloro-D-glucose (CAS 14685-79-1)
- Cholecalciferol Impurity 32 (CAS 89231-92-5)
- Mirogabalin Impurity 128 (CAS CATO-C4X-2924128)
- Amoxicillin Impurity 28 (CAS 37727-80-3)
- 4,4-Difluoro-2-phenylbutanoic acid (CAS 1375474-59-1)
- N-(4-Acetyl-3,5-dimethylphenyl)acetamide (CAS 100923-73-7)
- Ethyl 2-(2-chloroacetyl)-3-[(4-methoxyphenyl)amino]but-2-enoate (CAS 791607-31-3)
- (E)-3-(dimethylamino)-1-(pyridin-2-yl)but-2-en-1-one (CAS 112677-15-3)
- (2S,4S)-Methyl 4-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-2-carboxylate (CAS 2098959-95-4)
- 1H-pyrrolo[2,3-b]pyridine-6-carbaldehyde (CAS 898746-46-8)
- Des-[Gly]31-Semaglutide (CAS CATO-C4X-2226156)
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