Ritonavir EP Impurity N CAS 202816-62-4
| CAS No. | 202816-62-4 |
| Molecular Formula | C37H48N6O5S2 |
| Molecular Weight | 720.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Ritonavir EP Impurity N (C37H48N6O5S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 720.94 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Ritonavir EP Impurity N (CAS 202816-62-4, C37H48N6O5S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ritonavir EP Impurity N meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H48N6O5S2 |
| Molecular Weight | 720.94 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Ritonavir Standards
- Ritonavir (CAS 155213-67-5)
- Ritonavir Geo-isomer (CAS 959315-21-0)
- Ritonavir EP Impurity O (CAS 1414933-81-5)
- Ritonavir EP Impurity Q (CAS 1414933-82-6)
- Ritonavir EP Impurity R (CAS 1414933-80-4)
- Ritonavir impurity 48 (CAS CATO-C4X-175148)
- Ritonavir Impurity 56 (CAS CATO-C4X-175156)
- Ritonavir Dehydro (CAS 1156504-13-0)
Recommended Standards
- N1-(1-Benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl)-N2-{[[(5-isopropyl-1,3-thiazol-2-yl)methyl](methyl)amino]carbonyl}valinamide (CAS 2096495-89-3)
- N,N'-Bis(9,9-dimethyl-9H-fluoren-2-yl)-N,N'-diphenylbenzidine (CAS 361486-60-4)
- Azithromycin EP Impurity E (CAS 612069-27-9)
- Azithromycin Impurity 34 (CAS CATO-C4X-100334)
- Cefpirome Impurity 7 (CAS CATO-C4X-12077)
- Aprepitant Impurity 17 (CAS 1333998-27-8)
- Trametinib impurity 01 (CAS 871701-87-0)
- 5-Chloro-2-iodo-3-nitrobenzoic acid (CAS 855471-33-9)
- 1,4-Dimethyl-2,5-dinitrobenzene (CAS 712-32-3)
- 4-Nitrophenyl prop-2-yn-1-yl carbonate (CAS 228111-40-8)
- 6-Amino-2-piperidin-1-ylpyrimidin-4(3H)-one (CAS 76750-95-3)
- Nilotinib Impurity 21 (CAS CATO-C4X-125621)
- (2 β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)-pregnan-20-one (CAS 156685-94-8)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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