Rivaroxaban EP Impurity H CAS 1770812-37-7
| CAS No. | 1770812-37-7 |
| Molecular Formula | C19H17Cl2N3O5S |
| Molecular Weight | 470.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C19H17Cl2N3O5S, Rivaroxaban EP Impurity H contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 470.33 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Rivaroxaban EP Impurity H (CAS 1770812-37-7, C19H17Cl2N3O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rivaroxaban EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17Cl2N3O5S |
| Molecular Weight | 470.33 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity N8 (CAS 1770812-38-8)
- Rivaroxaban Impurity 200 (CAS CATO-C4X-1090200)
- Rivaroxaban Impurity 26 (CAS CATO-C4X-109026)
- Rivaroxaban impurity 166 (CAS CATO-C4X-1090166)
- Rivaroxaban Impurity 178 (CAS CATO-C4X-1090178)
- Rivaroxaban impurity 192 (CAS CATO-C4X-1090192)
- Rivaroxaban Impurity 207 (CAS CATO-C4X-1090207)
- Rivaroxaban Impurity 202 (CAS CATO-C4X-1090202)
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