Rivaroxaban impurity 192 CAS CATO-C4X-1090192
| CAS No. | CATO-C4X-1090192 |
| Molecular Formula | C20H23ClN4O5S |
| Molecular Weight | 466.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rivaroxaban impurity 192.
CATO supplies Rivaroxaban impurity 192 (CAS CATO-C4X-1090192), a pharmacopoeial impurity reference standard (molecular formula C20H23ClN4O5S, MW 466.94 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Rivaroxaban impurity 192 (C20H23ClN4O5S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rivaroxaban impurity 192 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H23ClN4O5S |
| Molecular Weight | 466.94 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 178 (CAS CATO-C4X-1090178)
- Rivaroxaban Impurity 207 (CAS CATO-C4X-1090207)
- Rivaroxaban impurity 166 (CAS CATO-C4X-1090166)
- Rivaroxaban Impurity 202 (CAS CATO-C4X-1090202)
- Rivaroxaban Impurity 203 (CAS CATO-C4X-1090203)
- Rivaroxaban Impurity 217 (CAS CATO-C4X-1090217)
- Rivaroxaban Impurity 26 (CAS CATO-C4X-109026)
- Rivaroxaban Impurity N8 (CAS 1770812-38-8)
Recommended Standards
- Mometasone Impurity C84 (CAS 722495-06-9)
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- Empagliflozin impurity 192 (CAS CATO-C4X-1065192)
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- 1-(4-Bromo-2-hydroxyphenyl)propan-1-one (CAS 17764-92-0)
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