N-(4-Phenoxyphenyl)-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxamide CAS 1775546-75-2
| CAS No. | 1775546-75-2 |
| Molecular Formula | C23H21F3N4O2 |
| Molecular Weight | 442.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(4-Phenoxyphenyl)-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-(4-Phenoxyphenyl)-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxamide (CAS 1775546-75-2), molecular formula C23H21F3N4O2 and molecular weight 442.43 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(4-Phenoxyphenyl)-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxamide (C23H21F3N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-Phenoxyphenyl)-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H21F3N4O2 |
| Molecular Weight | 442.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 262441-40-7)
- 1,2-Bis(4'-phenoxyphenyl)-1,1,2,2-tetrafluoroethane (CAS 149963-10-0)
- (4-Phenoxyphenyl)(4-tosylpiperazin-1-yl)methanone (CAS 941015-30-1)
- N-(4-Phenoxyphenyl)-4-(3-phenylpropanamido)benzamide (CAS 1027971-34-1)
- 1-[7-(4-Phenoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-4-phenylpiperazine (CAS 338403-75-1)
- N-(4-phenoxyphenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-amine (CAS 241488-37-9)
- 2-(4-phenoxyphenyl)-7-(4-piperidyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide (CAS 1633350-04-5)
- (4E)-2-{[(4-phenoxyphenyl)carbamoyl]methyl}tetradec-4-enoic acid (CAS 1024686-26-7)
Recommended Standards
- (S)-2-(4-(((2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl)(methyl)amino)benzamido)pentanedioic acid (CAS 156595-85-6)
- (S)-WSD0922 (CAS 2226552-65-2)
- 3-{3-tert-butyl-1-methyl-4-oxo-1H,4H-indeno[1,2-c]pyrazol-6-yl}-1-[3-(trifluoromethyl)phenyl]urea (CAS 1119392-37-8)
- 1-(3-Cyano-1-(4-methoxybenzyl)-4,5-dimethyl-1H-pyrrol-2-yl)-3-(3-(trifluoromethyl)phenyl)urea (CAS 866017-62-1)
- (1R,2S,3R,4S)-3-Amino-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid (CAS 1820571-65-0)
- 5-Cyclopropylthiazole-2-carboxylic acid (CAS 1892415-56-3)
- Cyclobutyl(naphthalen-1-yl)methanamine hydrochloride (CAS 1864062-90-7)
- tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate hydrochloride (CAS 1955507-01-3)
- Methyl 4-amino-6-bromonicotinate (CAS 1256794-50-9)
- Methyl 5-(6-methoxynicotinoyl)-2- furanoate (CAS 898786-26-0)
- 1-(Dimethylamino)cyclobutanecarbonitrile (CAS 176445-74-2)
- 2-Bromo-3-bromomethyl-4-(trifluoromethyl)pyridine (CAS 1227516-34-8)
- (3-Bromo-5-chlorophenyl)(4-methylpiperazin-1-yl)methanone (CAS 312537-17-0)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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