Raloxifene Impurity 5 CAS 177744-96-6
| CAS No. | 177744-96-6 |
| Molecular Formula | C21H14O4S |
| Molecular Weight | 362.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Raloxifene Impurity 5 (CAS 177744-96-6) is a certified pharmaceutical impurity reference standard with the molecular formula C21H14O4S and a molecular weight of 362.40 g/mol.
The molecular framework of Raloxifene Impurity 5 (C21H14O4S) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H14O4S |
| Molecular Weight | 362.40 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Sulfur Atoms | 1 |
Related Raloxifene Standards
- Raloxifene Impurity 3 (CAS 1677681-02-5)
- Raloxifene Impurity 3 (CAS 84449-65-0)
- Raloxifene Impurity 20 (CAS 182133-38-6)
- Raloxifene Impurity 24 (CAS CATO-C4X-174324)
- Raloxifene Impurity 4 (CAS 1191901-07-1)
- Raloxifene Impurity 28 (CAS 13664-92-1)
- Raloxifene Impurity N65 (CAS 63675-73-0)
- Raloxifene Impurity 31 (CAS 63762-93-6)
Recommended Standards
- LCZ-696 Impurity 84 (CAS 5717-37-3)
- Bumetanide Impurity 122 (CAS CATO-C4X-1986122)
- Glipizide Impurity 45 (CAS CATO-C4X-140745)
- Bumetanide Impurity 99 (CAS CATO-C4X-198699)
- Abiraterone Impurity 13 (CAS 154229-20-6)
- Artemisinin Impurity 9 (CAS CATO-C4X-20129)
- Azelastine Impurity 11 3HCl (CAS 169123-29-9)
- Ethyl 7-(3,4-dichlorophenyl)-5-propyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate (CAS 5518-63-8)
- 6-Ethoxy-N-methoxy-N-methylnicotinamide (CAS 1198164-32-7)
- 2-((Thiophen-2-ylthio)methyl)benzofuran (CAS 88673-95-4)
- Methyl 3-[2-(dimethylsulfamoyl)phenyl]-5-fluorobenzoate (CAS 1820734-79-9)
- 1,2-Dihydro-5-phenylpyrazol-3-one, 97% (CAS 27412-71-1)
- (3-Amino-5-nitrophenyl)(piperidin-1-yl)methanone (CAS 696631-19-3)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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