(3-Chloro-6-fluoro-2-methoxyphenyl)methanol CAS 1780183-58-5
| CAS No. | 1780183-58-5 |
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(3-Chloro-6-fluoro-2-methoxyphenyl)methanol (CAS 1780183-58-5), molecular formula C8H8ClFO2 and molecular weight 190.60 g/mol, is a CATO reference standard with documented purity and traceability.
(3-Chloro-6-fluoro-2-methoxyphenyl)methanol (C8H8ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (3-Chloro-6-fluoro-2-methoxyphenyl)methanol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-4-ethoxy-5-fluorophenol (CAS 1017778-82-3)
- 2-Chloro-4-ethyl-5-fluoro-6-methoxypyrimidine (CAS 1192479-51-8)
- (5-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1266177-72-3)
- 5-Chloro-3-fluoro-2-(2-hydroxyethylamino)pyridine (CAS 1280786-67-5)
- 4-Chloro-2-fluoro-3-methoxybenzyl alcohol (CAS 1323966-21-7)
- (R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol, 97% (CAS 1453854-84-6)
- 1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol (CAS 1558116-77-0)
- (3-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1616601-81-0)
Recommended Standards
- 3-Chloro-5-fluoro-2-methoxybenzyl alcohol (CAS 1785513-23-6)
- 1-Chloro-2,3-dimethoxy-4-fluorobenzene (CAS 1804409-83-3)
- 1-Ethyl-5-fluoro-3-methyl-1H-pyrazole-4-carbonyl chloride (CAS 1823464-69-2)
- 2-Chloro-4-ethoxy-3-fluorophenol (CAS 1823779-02-7)
- Pyrroloquinoline Impurity 3 (CAS 107575-59-7)
- 2-oxo-2,3-dihydro-1-benzofuran-7-carboxylic acid (CAS 855221-95-3)
- 7-Hydroxy-DPAT (CAS 74938-11-7)
- Methyl 5-amino-2-[2-(propan-2-yl)piperazin-1-yl]-benzoate (CAS 1242268-13-8)
- 2,4-Dichloro-1-(1,1-difluoroethyl)benzene (CAS 1204295-92-0)
- tert-Butyl 3-(((3-(4-methylpiperazin-1-yl)propyl)amino)methyl)pyrrolidine-1-carboxylate (CAS 887591-45-9)
- Ethyl 3-amino-1-methyl-1H-pyrazole-5-carboxylate hydrochloride (CAS 1197228-34-4)
- (E)-2-((5-bromo-2-hydroxybenzylidene)amino)isoindoline-1,3-dione (CAS 98841-63-5)
- CAS 228402-49-1 (CAS 228402-49-1)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
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