1-Chloro-2,3-dimethoxy-4-fluorobenzene CAS 1804409-83-3
| CAS No. | 1804409-83-3 |
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Chloro-2,3-dimethoxy-4-fluorobenzene.
CATO supplies 1-Chloro-2,3-dimethoxy-4-fluorobenzene (CAS 1804409-83-3), a certified reference material (molecular formula C8H8ClFO2, MW 190.60 g/mol) for analytical method development and quality control.
The molecular framework of 1-Chloro-2,3-dimethoxy-4-fluorobenzene (C8H8ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-4-ethoxy-5-fluorophenol (CAS 1017778-82-3)
- 2-Chloro-4-ethyl-5-fluoro-6-methoxypyrimidine (CAS 1192479-51-8)
- (5-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1266177-72-3)
- 5-Chloro-3-fluoro-2-(2-hydroxyethylamino)pyridine (CAS 1280786-67-5)
- 4-Chloro-2-fluoro-3-methoxybenzyl alcohol (CAS 1323966-21-7)
- (R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol, 97% (CAS 1453854-84-6)
- 1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol (CAS 1558116-77-0)
- (3-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1616601-81-0)
Recommended Standards
- 3-Chloro-5-fluoro-2-methoxybenzyl alcohol (CAS 1785513-23-6)
- 1-Ethyl-5-fluoro-3-methyl-1H-pyrazole-4-carbonyl chloride (CAS 1823464-69-2)
- (3-Chloro-6-fluoro-2-methoxyphenyl)methanol (CAS 1780183-58-5)
- 2-Chloro-4-ethoxy-3-fluorophenol (CAS 1823779-02-7)
- N-(2-(Azepan-1-yl)-2-(thiophen-3-yl)ethyl)-3-fluorobenzamide (CAS 954622-21-0)
- 5-Fluoro-3-methyl-2-nitrobenzoic acid (CAS 952479-96-8)
- 6-Chloro-4-methyl-1,3,5-triazin-2(1H)-one (CAS 1303967-52-3)
- Estriol 3-Succinate (CAS 47575-61-1)
- 4-(2-Bromobenzylidene)-2-(4-nitrophenyl)oxazol-5(4H)-one (CAS 90124-88-2)
- 5-(Bromomethyl)oxazole (CAS 127232-42-2)
- 3-Chloro-4-[2-(2-methoxyethoxy)ethoxy]anilinehydrochloride (CAS 1185295-26-4)
- Formoterol Impurity 51 HCl (CAS 2386293-34-9(Free Base))
- (S)-2-((tert-Butoxycarbonyl)(methyl)amino)-2-(4-methoxyphenyl)acetic acid (CAS 1821790-88-8)
- Semaglutide Impurity 158 (x TFA Salt) (CAS CATO-C4X-2226158)
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