5-Bromo-4-(difluoromethyl)pyrimidine CAS 1780524-96-0
| CAS No. | 1780524-96-0 |
| Molecular Formula | C5H3BrF2N2 |
| Molecular Weight | 208.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Bromo-4-(difluoromethyl)pyrimidine (CAS 1780524-96-0), molecular formula C5H3BrF2N2 and molecular weight 208.99 g/mol, is a CATO reference standard with documented purity and traceability.
5-Bromo-4-(difluoromethyl)pyrimidine (C5H3BrF2N2) contains a nitrile group, fluorine/bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Bromo-4-(difluoromethyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H3BrF2N2 |
| Molecular Weight | 208.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 4-Bromo-2,6-difluorophenol (CAS 104197-13-9)
- 2-Bromo-3,6-difluorophenol (CAS 1208077-18-2)
- (Z)-3-bromo-4-methoxy-4-oxobut-2-enoic acid (CAS 122457-36-7)
- 5-Bromo-3,6-difluoropyridin-2-amine (CAS 1267856-70-1)
- 4-Bromo-3,5-difluorophenol (CAS 130191-91-2)
- 2-Bromo-3,4-difluorophenol (CAS 1376335-05-5)
- 4-Bromo-2,3-difluorophenol (CAS 144292-32-0)
- 3-Bromo-2,4-difluorophenol (CAS 1541784-30-8)
Recommended Standards
- 4-Bromo-6-(difluoromethyl)pyrimidine (CAS 1706448-11-4)
- 5-Bromo-2-(difluoromethyl)pyrimidine (CAS 1780834-92-5)
- 4-Iodo-1H-pyrazol-1-amine (CAS 1706448-04-5)
- 3-Bromo-2,5-difluorophenol (CAS 1783357-67-4)
- 5-Amino-6-bromo-1H-indazole (CAS 1360928-41-1)
- 3-Chloro-4-ethoxybenzoic Acid (CAS 213598-15-3)
- rel-(1R,2R)-2-(2-Bromophenyl)cyclopropane-1-carboxylic acid (CAS 175168-70-4)
- L-Menthylmethacrylate (CAS 2231-91-6)
- 2-Bromo-5-methyl-spiro[6H-thieno[3,2-c]pyridine-7,1'-cyclopentane]-4-one (CAS 2789682-27-3)
- Isoquinolin-8-yldimethylphosphine oxide (CAS 2741499-44-3)
- 2-Amino-3-(2-chloro-3-(trifluoromethyl)phenyl)propanoic acid (CAS 1259973-98-2)
- tert-Butyl 2-chloro-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate (CAS 1226898-92-5)
- 6-Methoxy-2-(trifluoromethyl)pyridine-3-acetic acid (CAS 1227581-28-3)
- Peptide Impurity 70 TFA Salt (CAS CATO-CPTD788570)
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