2,2-Difluoro-2-(tetrahydrofuran-3-yl)acetic acid CAS 1781025-79-3
| CAS No. | 1781025-79-3 |
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2,2-Difluoro-2-(tetrahydrofuran-3-yl)acetic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2,2-Difluoro-2-(tetrahydrofuran-3-yl)acetic acid (CAS 1781025-79-3), molecular formula C6H8F2O3 and molecular weight 166.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,2-Difluoro-2-(tetrahydrofuran-3-yl)acetic acid (C6H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 2,2-difluoro-2-(furan-2-yl)acetic acid (CAS 1344257-62-0)
- 3,3-Difluoro-1-(hydroxymethyl)cyclobutane-1-carboxylic acid (CAS 1645565-01-0)
- 3,3-Difluoro-4-Methyl-2-Oxopentanoic Acid (CAS 165544-39-8)
- 2,2-Difluoro-2-(tetrahydrofuran-2-yl)acetic acid (CAS 170884-47-6)
- 4,4-Difluoro-3-methyltetrahydrofuran-3-carboxylic acid (CAS 1782346-79-5)
- 2,2-Difluoro-3,3-dihydroxycyclohexanone (CAS 183742-86-1)
- Methyl 2,2-difluoro-3-oxopentanoate (CAS 196202-01-4)
- 2-(3,3-Difluoro-1-hydroxycyclobutyl)acetic acid (CAS 2295815-26-6)
Recommended Standards
- 3-(1,1-Difluoroethyl)oxetane-3-carboxylic acid (CAS 1780909-55-8)
- 3-(Difluoromethoxy)cyclobutane-1-carboxylic acid (CAS 1803603-34-0)
- 5-(difluoromethyl)furan-3-carboxylic acid (CAS 1706447-96-2)
- 2-(difluoromethyl)furan-3-carboxylic acid (CAS 1655558-07-8)
- 2-((2-Methylquinolin-8-yl)oxy)ethan-1-amine (CAS 1094492-24-6)
- (2E)-3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-acryloyl chloride 1004644-49-8 7175AC C9H11ClN2O (CAS 1004644-49-8)
- rel-(3aR,6aR)-6a-(Methoxymethyl)hexahydro-2H-furo[2,3-c]pyrrole (CAS 2696258-05-4)
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- 1-(Tert-butyl) 2-methyl (2S,4R)-4-aminopiperidine-1,2-dicarboxylate (CAS 254882-17-2)
- 3,4-Dimercaptophenol (CAS 742080-42-8)
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- Potassium 2-((phosphonomethyl)amino)acetate (CAS 39600-42-5)
- N-(3-(2-Oxopyrrolidin-1-yl)phenyl)-2-phenylethane-1-sulfonamide (CAS 942013-01-6)
- Semaglutide impurity 41 (CAS CATO-C4X-222641)
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