2-(1-(Tert-butoxycarbonyl)azetidin-3-yl)-2,2-difluoroacetic acid CAS 1781091-41-5
| CAS No. | 1781091-41-5 |
| Molecular Formula | C10H15F2NO4 |
| Molecular Weight | 251.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(1-(Tert-butoxycarbonyl)azetidin-3-yl)-2,2-difluoroacetic acid (CAS 1781091-41-5), molecular formula C10H15F2NO4 and molecular weight 251.23 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 2-(1-(Tert-butoxycarbonyl)azetidin-3-yl)-2,2-difluoroacetic acid is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 251.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H15F2NO4 |
| Molecular Weight | 251.23 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Tert Standards
- 1-tert-butoxycarbonyl-4,4-difluoro-pyrrolidine-2-carboxylic acid (CAS 1000313-01-8)
- 1-((tert-Butoxycarbonyl)amino)-3,3-difluorocyclobutanecarboxylic acid (CAS 1363380-83-9)
- 2-((tert-Butoxycarbonyl)amino)-2-(2,2-difluorocyclopropyl)acetic acid (CAS 1393529-99-1)
- 1-(Tert-butoxycarbonyl)-3,4-difluoropyrrolidine-3-carboxylic acid (CAS 1781331-73-4)
- 1-(Tert-butoxycarbonyl)-3-(difluoromethyl)azetidine-3-carboxylic acid (CAS 1784562-69-1)
- 1-(((tert-Butoxycarbonyl)amino)methyl)-2,2-difluorocyclopropane-1-carboxylic acid (CAS 2228502-72-3)
- 3-(((Tert-butoxycarbonyl)amino)methyl)-2,2-difluorocyclopropane-1-carboxylic acid (CAS 2137627-21-3)
- 5-((Tert-butoxycarbonyl)amino)tetracyclo[3.2.0.0(2,7).0(4,6)]heptane-1-carboxylic acid (CAS 1212140-82-3)
Recommended Standards
- Methyl 2-[[5-(trifluoromethyl)-2-pyridyl]sulfanyl]acetate (CAS 142274-35-9)
- 1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid (CAS 1822567-84-9)
- 1-{[(2R,3R)-2-(2,3-Difluorophenyl)-3-methyloxiran-2-yl]methyl}-1H-1,2,3-triazole (CAS 1356090-35-1)
- 2-Ethoxy-5-fluoro-N-(4-fluorophenyl)pyrimidin-4-amine (CAS 1956334-57-8)
- (3-Azabicyclo[4.1.0]heptan-6-yl)methanol hydrochloride (CAS 1345728-52-0)
- 7-(Piperazin-1-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (CAS 1520554-42-0)
- 2-(3-Bromo-2-nitrophenyl)acetic acid (CAS 400629-31-4)
- (2-Aminopyrimidin-5-yl)dimethylphosphine oxide (CAS 2362008-83-9)
- bis(1-[2-(dimethylamino)ethyl]guanidine), sulfuric acid (CAS 905300-72-3)
- Ac-Val-OMe (CAS 1492-15-5)
- 5-Oxopyrrolidine-2-carbohydrazide (CAS 94135-34-9)
- 4-((3,4-Difluorobenzyl)amino)butan-2-ol (CAS 1339758-20-1)
- 7-Bromo-2-chloro-3-phenylquinoline (CAS 85274-44-8)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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