1-(Tert-butoxycarbonyl)-3-(difluoromethyl)azetidine-3-carboxylic acid CAS 1784562-69-1
| CAS No. | 1784562-69-1 |
| Molecular Formula | C10H15F2NO4 |
| Molecular Weight | 251.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(Tert-butoxycarbonyl)-3-(difluoromethyl)azetidine-3-carboxylic acid (C10H15F2NO4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
1-(Tert-butoxycarbonyl)-3-(difluoromethyl)azetidine-3-carboxylic acid (CAS 1784562-69-1), molecular formula C10H15F2NO4 and molecular weight 251.23 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15F2NO4 |
| Molecular Weight | 251.23 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Tert Standards
- 1-tert-butoxycarbonyl-4,4-difluoro-pyrrolidine-2-carboxylic acid (CAS 1000313-01-8)
- 1-((tert-Butoxycarbonyl)amino)-3,3-difluorocyclobutanecarboxylic acid (CAS 1363380-83-9)
- 2-((tert-Butoxycarbonyl)amino)-2-(2,2-difluorocyclopropyl)acetic acid (CAS 1393529-99-1)
- 2-(1-(Tert-butoxycarbonyl)azetidin-3-yl)-2,2-difluoroacetic acid (CAS 1781091-41-5)
- 1-(Tert-butoxycarbonyl)-3,4-difluoropyrrolidine-3-carboxylic acid (CAS 1781331-73-4)
- 1-(((tert-Butoxycarbonyl)amino)methyl)-2,2-difluorocyclopropane-1-carboxylic acid (CAS 2228502-72-3)
- 3-(((Tert-butoxycarbonyl)amino)methyl)-2,2-difluorocyclopropane-1-carboxylic acid (CAS 2137627-21-3)
- 5-((Tert-butoxycarbonyl)amino)tetracyclo[3.2.0.0(2,7).0(4,6)]heptane-1-carboxylic acid (CAS 1212140-82-3)
Recommended Standards
- 1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid (CAS 1822567-84-9)
- 2-Ethoxy-5-fluoro-N-(4-fluorophenyl)pyrimidin-4-amine (CAS 1956334-57-8)
- Methyl 2-[[5-(trifluoromethyl)-2-pyridyl]sulfanyl]acetate (CAS 142274-35-9)
- (2R)-1-tert-butoxycarbonyl-4,4-difluoro-pyrrolidine-2-carboxylic acid (CAS 536747-87-2)
- Methyl 3-(aminomethyl)-2-hydroxyhexanoate (CAS 1518185-94-8)
- 1-Boc-4-(Cbz-amino)-3-pyrrolidinone (CAS 288083-67-0)
- 4-Amino-3-isopropyl-1H-pyrazole-5-carboxamide (CAS 521300-03-8)
- 2-(3-Amino-4-(difluoromethoxy)benzoyl)pyridine (CAS 1261800-46-7)
- 1-Ethyl-1H-pyrrole-2-carboxaldehyde (CAS 2167-14-8)
- (R)-1-(2-(Trifluoromethyl)phenyl)ethanamine hydrochloride (CAS 865815-07-2)
- 5-Bromo-4-chloro-2-(methylthio)thieno[2,3-d]pyrimidine (CAS 1823552-34-6)
- 2-Amino-N-phenyldibenzo[b,d]thiophene (CAS 1300028-91-4)
- (1-(3,4-Dichlorophenyl)cyclopropyl)methanamine hydrochloride (CAS 1260423-20-8)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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