1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid CAS 1822567-84-9
| CAS No. | 1822567-84-9 |
| Molecular Formula | C10H15F2NO4 |
| Molecular Weight | 251.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid (CAS 1822567-84-9), molecular formula C10H15F2NO4 and molecular weight 251.23 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid (C10H15F2NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-[(tert-butoxy)carbonyl]-3,3-difluoropyrrolidine-2-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H15F2NO4 |
| Molecular Weight | 251.23 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related tert Standards
- 1-[(Tert-butoxy)carbonyl]-4,4-difluoropyrrolidine-3-carboxylic acid (CAS 1196145-11-5)
- 1-(tert-Butoxy)-4-cyclopropoxy-2-nitrobenzene (CAS 1243311-34-3)
- 4-(tert-Butoxy)-2-cyclopropoxy-1-nitrobenzene (CAS 1243346-55-5)
- 3-(tert-Butoxy)-5-cyclopropoxyisonicotinic acid (CAS 1243346-58-8)
- 2-(tert-Butoxy)-4-cyclopropoxynicotinic acid (CAS 1243357-42-7)
- 6-(tert-Butoxy)-4-cyclopropoxynicotinic acid (CAS 1243375-13-4)
- 2-(tert-Butoxy)-4-cyclopropoxy-1-nitrobenzene (CAS 1243385-72-9)
- 2-(tert-Butoxy)-1-cyclopropoxy-4-nitrobenzene (CAS 1243393-11-4)
Recommended Standards
- 1-(Tert-butoxycarbonyl)-3-(difluoromethyl)azetidine-3-carboxylic acid (CAS 1784562-69-1)
- 2-Ethoxy-5-fluoro-N-(4-fluorophenyl)pyrimidin-4-amine (CAS 1956334-57-8)
- 1-(Tert-butoxycarbonyl)-3,4-difluoropyrrolidine-3-carboxylic acid (CAS 1781331-73-4)
- (2R)-1-tert-butoxycarbonyl-4,4-difluoro-pyrrolidine-2-carboxylic acid (CAS 536747-87-2)
- 2,2-Dimethyl-4-oxo-4-(2,4,6-trimethylphenyl)butyric acid (CAS 867130-04-9)
- 5-Methyl-3-(trifluoromethyl)isoxazole (CAS 111079-03-9)
- Ethyl (2S,3S)-3-methyloxirane-2-carboxylate (CAS 110508-08-2)
- Itopride Impurity 20 (CAS 131028-54-1)
- rel-(3aS,6S,6aR)-3a,5,6,6a-Tetrahydrofuro[2,3-d]oxazole-2,6-diamine dihydrochloride (CAS 2742667-26-9)
- 4-Chloro-5-fluoropyridin-3-ol (CAS 1393553-75-7)
- Boc-D-Phe(4-Br)-OH (CAS 79561-82-3)
- Methyl 6-(cyanomethyl)nicotinate (CAS 1000529-39-4)
- N,N-Diethyl-6,8,8,9,11,11,12,14,14,15,15,16,16,16-tetradecafluoro-N-methyl-5-oxo-6,9,12-tris(trifluoromethyl)-7,10,13-trioxa-4-azahexadecan-1-aminium iodide (CAS 84166-37-0)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
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