2-(Difluoromethyl)pyrimidin-5-amine CAS 1781133-28-5
| CAS No. | 1781133-28-5 |
| Molecular Formula | C5H5F2N3 |
| Molecular Weight | 145.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 145.11 g/mol gives 2-(Difluoromethyl)pyrimidin-5-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(Difluoromethyl)pyrimidin-5-amine (CAS 1781133-28-5), molecular formula C5H5F2N3 and molecular weight 145.11 g/mol, is a CATO reference standard with documented purity and traceability.
2-(Difluoromethyl)pyrimidin-5-amine (C5H5F2N3) contains a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(Difluoromethyl)pyrimidin-5-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F2N3 |
| Molecular Weight | 145.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluoromethyl Standards
- 5-(Difluoromethyl)pyridin-3-ol (CAS 1393541-20-2)
- 5-(Difluoromethyl)-2(1H)-pyridinone 1402550-75-7 5-(Difluoromethyl)pyridin-2(1H)-one (CAS 1402550-75-7)
- 1-(difluoromethyl)-1H-pyrrole-2-carbaldehyde (CAS 1519187-90-6)
- 6-(Difluoromethyl)pyrimidin-4-amine (CAS 1706464-15-4)
- 4-(Difluoromethyl)pyridin-2(1H)-one (CAS 1780500-70-0)
- 4-(Difluoromethyl)pyrimidin-2-amine (CAS 1780891-13-5)
- 3-(Difluoromethyl)pyrazin-2-amine (CAS 1785423-85-9)
- 4-(Difluoromethyl)pyridin-3-ol (CAS 1803997-29-6)
Recommended Standards
- 2,5-Difluoro-3-hydroxyaniline (CAS 1803836-24-9)
- Methyl 5-hydroxy-4,5-dihydroisoxazole-3-carboxylate (CAS 170648-38-1)
- (4,5-Difluoropyridin-2-yl)methanol (CAS 1803846-94-7)
- 2,6-Difluoro-N-methylpyrimidin-4-amine (CAS 165258-58-2)
- Isopropyl 2-((4-(4-chlorophenyl)-3-cyano-6-(p-tolyl)pyridin-2-yl)thio)acetate (CAS 444153-80-4)
- 6-thia-2,4,10,13-tetraazatricyclo[7.4.0.0³,⁷]trideca-1(13),2,4,7,9,11-hexaen-5-amine (CAS 119151-73-4)
- (4-Fluorophenyl)(3-nitrophenyl)methanone (CAS 16574-53-1)
- 6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride (CAS 1373223-69-8)
- 4-Methyl-1H-benzo[d]imidazole-6-carboxylic acid (CAS 398452-96-5)
- 4-Bromopyridine-3-boronic acid pinacol ester (CAS 2096334-82-4)
- 4-Amino-2-iodopyridin-3-ol (CAS 1171919-81-5)
- Mavacamten Impurity 20 (CAS CATO-C4X-298220)
- N-(2-(Furan-2-yl)-2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)acetamide (CAS 62130-06-7)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
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