2,6-Difluoro-N-methylpyrimidin-4-amine CAS 165258-58-2
| CAS No. | 165258-58-2 |
| Molecular Formula | C5H5F2N3 |
| Molecular Weight | 145.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2,6-Difluoro-N-methylpyrimidin-4-amine (CAS 165258-58-2), molecular formula C5H5F2N3 and molecular weight 145.11 g/mol, is a CATO reference standard with documented purity and traceability.
2,6-Difluoro-N-methylpyrimidin-4-amine (C5H5F2N3) contains a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5F2N3 |
| Molecular Weight | 145.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluoro Standards
- (2,6-Difluoro-3-pyridyl)methanol (CAS 1105510-11-9)
- 3,5-Difluoro-2-methoxypyridine (CAS 1171918-06-1)
- 2,6-Difluoro-4-methoxypyridine (CAS 1184172-35-7)
- 3,5-Difluoro-4-methoxypyridine (CAS 1186195-24-3)
- 2,5-Difluoro-4-methoxypyridine (CAS 1210868-65-7)
- 3,6-Difluoro-2-methoxypyridine (CAS 1214323-06-4)
- 2,6-Difluoro-3-methoxypyridine (CAS 1214331-52-8)
- 2,3-Difluoro-6-methoxypyridine (CAS 1227564-48-8)
Recommended Standards
- 4,6-Difluoro-N-methylpyrimidin-2-amine (CAS 165258-57-1)
- 6-(Difluoromethyl)pyrimidin-4-amine (CAS 1706464-15-4)
- 2-Amino-4,5-difluorophenol (CAS 163734-01-8)
- Methyl 5-hydroxy-4,5-dihydroisoxazole-3-carboxylate (CAS 170648-38-1)
- N-methyl-2-(3-(pyridin-3-yl)-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carbonyl)hydrazine-1-carbothioamide (CAS 551921-18-7)
- 5-Bromobufuralol HCl (CAS 137740-36-4)
- N-(3,5-Bis(trifluoromethyl)phenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 556802-21-2)
- N-(3-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (CAS 1604802-44-9)
- Abiraterone Impurity N6 (CAS 853-23-6)
- tert-Butyl (R)-2-(2-chloroacetyl)piperidine-1-carboxylate (CAS 1260606-86-7)
- 7-(1-(2,4-Dichlorophenoxy)ethyl)-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 338403-67-1)
- 4,4'-(Thiophene-2,5-diyl)dibenzonitrile (CAS 55368-38-2)
- 4,6-Dimethyl-2-(piperazin-1-yl)pyrimidine hydrochloride (CAS 88268-19-3)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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